BLOCKsynop develops the Neural Blockade Monitor, a noninvasive device designed to give anesthesiologists objective, real-time measurements of regional nerve-block effectiveness. Established after CTO Wayne Sternberger received the inaugural Johns Hopkins University Applied Physics Laboratory Archimedes Award in 2020, the company grew from collaboration between systems engineering and pediatric anesthesiology. Its second-generation prototype has been validated in studies involving adult and pediatric anesthesia, while remaining investigational and not approved for sale in the United States.
NeuroWave Systems IncFormed in 2003, Beachwood-based NeuroWave Systems develops and manufactures brain-monitoring and drug-delivery medical devices for anesthesia, critical care, and military medicine. Its NeuroSENSE® monitor stands apart by displaying independent, real-time measures of anesthetic effect for each brain hemisphere, while the company also develops closed-loop systems intended to automate sedation and anesthesia delivery. NeuroWave is an ISO 13485 medical device company with expertise spanning EEG signal processing, control engineering, and medical-device software.BEACHWOOD, OH
Somnair SleepSomnair Sleep is developing a first-in-class, non-invasive neurostimulation device intended to open the airway for people with obstructive sleep apnea. The company’s multidisciplinary founding team brings together otolaryngology, mechanical engineering, electromechanical design and biomedical device validation experience, while the Somnair device remains in pre-clinical development ahead of planned clinical studies.BALTIMORE, MD
IDMED CorpIDMED Corp. develops and markets medical monitoring devices for anesthesia and intensive care, including the NeuroLight® automated pupillometer and ToFscan® neuromuscular blockade monitor. The U.S. company is part of French manufacturer IDMED, whose devices are used worldwide and developed in collaboration with healthcare professionals. Its ToFscan stands out for three-dimensional sensor technology that requires no calibration before use, while NeuroLight turns pupil size and reactivity into traceable bedside measurements for neurological assessment.C O PRAMEX INTERNATIONAL, NY
Active Signal Technologies, IncActive Signal Technologies was founded in 1996 by members of Lockheed Martin’s advanced sensor and solid-state actuator group, carrying that research background into specialized device development. The Maryland company’s work is especially associated with the Brain Acoustic Monitor, a portable system developed for noninvasive assessment of traumatic brain injury in military, hospital, and emergency-care settings. It also developed a noise-immune stethoscope for clinicians working in aircraft and other extremely loud environments.LINTHICUM HEIGHTS, MD