Founded in Ohio in 1979, CSafe makes temperature-controlled shipping systems that protect life-science products from the manufacturer to the patient. Its active and passive cold-chain packaging is paired with qualification services and CSafe Connect real-time shipment visibility, supporting deliveries across more than 185 countries. The company says its products have safely carried more than 10 billion doses.
ISO 9001 – Quality System
ISO 14001 – Environmental
ISO 45001 – Health and Safety
ISO 13485 – Medical Device
United States Food and Drug Administration (FDA) 21 CFR Part 820
Compliance program
Accord Transport Perishables (ATP)
Compliance program
MDR – CE Medical Device Requirement
Compliance program
Federal Aviation Administration (FAA) Part 145
Registration
European Union Aviation Safety Agency (EASA) Part 145
Registration
Federal Aviation Administration (FAA) Part 21
Registration
ATP
Quality certification
CEMARKING
Quality certification
MDR
Quality certification
ThermoSafeWith more than 120 years of packaging experience, ThermoSafe designs temperature-controlled packaging for pharmaceuticals, biologics, vaccines, food and other sensitive goods. Its ISC Labs pair engineering and thermal testing with pre-qualified shipping systems, reusable rental containers and digital monitoring, serving customers through a global network of 30 locations across the Americas, Europe and Asia. The company also applies its thermal and materials expertise to AliveTide coolers, manufactured in the United States for outdoor use.ROCKVILLE, MD
Cold Chain TechnologiesFor more than 50 years, Cold Chain Technologies has engineered and supplied reusable and sustainable thermal packaging and digital systems that protect temperature-sensitive life sciences shipments. Based in the United States with a global service network, CCT combines ISTA-certified testing, thermal engineering, monitoring, and hands-on cold chain support for pharmaceutical and biotech supply chains. The company is ISO 9001:2015 certified and has shipped more than 15 million reusable and sustainable systems worldwide.BETHLEHEM, PA
Temprecision InternationalFormed in 2018 from Smithers-Oasis’s temperature-control work, Temprecision International makes performance foams and refrigerant bricks for temperature-controlled shipping. Its ThermaBrick® system combines proprietary foam with phase-change materials to protect sensitive cargo, while its research-led teams develop and test custom cold-chain packaging for demanding applications. The company operates manufacturing facilities in 14 countries, seven research laboratories in five countries, and sells to more than 130 countries.KENT, OH
AeroSafe GlobalFrom Rochester, AeroSafe Global manages temperature-sensitive pharmaceutical deliveries through its proprietary Cold Chain as a Service model, combining digitally enabled thermal packaging with end-to-end logistics intelligence. The company serves customers in 80 countries with capacity for 11 million shipments annually and has safeguarded 40 billion therapies. Its full-cycle reuse program has operated for more than a decade, recovering reusable transport containers across 85 countries.ROCHESTER, NY