Formed by UPMC Enterprises, Generian Pharmaceuticals is a Boston- and Pittsburgh-based preclinical biotechnology company developing orally available small-molecule therapeutics for difficult-to-drug diseases often dominated by biologics. Its discovery platform screens proteins in their native cellular environment, then combines target-binding data with disease-relevant phenotypic testing to advance candidates that modulate protein activity, stability, or degradation. The company’s research includes proprietary programs and a collaboration with Astellas for novel targets.
Noveome Biotherapeutics, IncNoveome Biotherapeutics is a Pittsburgh-based clinical-stage biopharmaceutical company developing ST266, a non-cellular biologic derived from the secretome of cultured amnion-derived epithelial cells. Its scalable GMP process produces the investigational biologic for research and clinical development across challenging diseases and conditions, with the company describing activity in clinical and preclinical studies.PITTSBURGH, PA
AUM LifeTech, IncPhiladelphia-based AUM LifeTech develops RNA-targeting therapeutics through its proprietary AUM silence antisense oligonucleotide platform, which is designed to silence or regulate disease-linked RNA without an external delivery vehicle. Founded by biotechnology entrepreneur Veenu Aishwarya, the company is pursuing preclinical treatments for genetically defined diseases, including an anti-FOXP3 cancer-immunotherapy program developed with Children’s Hospital of Philadelphia. Its work also includes a Parkinson’s disease program conducted with the University of Pennsylvania.PHILADELPHIA, PA
Rapafusyn PharmaceuticalsEmerging from Johns Hopkins professor Jun O. Liu’s laboratory, Rapafusyn Pharmaceuticals develops non-degrading molecular-glue medicines designed to reach hard-to-drug intracellular and transmembrane targets. Based on its RapaGlue™ platform, the Baltimore biotech is advancing an early pipeline that includes an ENT1 inhibitor for acute kidney injury, an area where the company says no approved preventive therapies exist. Its discovery engine combines AI-enabled machine learning with a DNA-encoded library containing more than 8 billion non-degrading glues.BALTIMORE, MD
Amgen IncFounded in Thousand Oaks, California, in 1980 as Applied Molecular Genetics Inc., Amgen is a biotechnology company that discovers, develops and manufactures medicines. It uses living cells to make biologic medicines and has grown into a global company with a presence in approximately 100 countries. Its work includes medicines for serious illnesses across general medicine, rare disease, inflammation and oncology.NEW ALBANY, OH