Founded in 2002, Oberlin-based Synapse Biomedical develops and manufactures neurostimulation medical devices that help patients breathe and recover movement. Its FDA-approved NeuRx Diaphragm Pacing System supports diaphragm conditioning for people with spinal cord injuries and ALS, while the company’s TransAeris system is designed to address ventilator-induced diaphragm dysfunction. Synapse says its NeuRx products are manufactured in Ohio at an ISO 13485-certified facility and have been used to treat more than 2,000 patients.
ISO 13485:2003
FDA Cleared
CE Mark Approved
Health Canada Approved
FDA
Quality certification
Avery Biomedical Devices, IncFounded by Roger Avery in the late 1960s, Avery Biomedical Devices makes implanted diaphragm pacemaker systems that stimulate the phrenic nerves to support breathing. The company’s predecessor introduced the first commercially distributed diaphragm pacemaker in 1971, and Avery has since manufactured more than 10,000 neurostimulators implanted in over 50 countries. Renamed in 2005, the Long Island manufacturer’s Spirit system has full FDA approval for adult and pediatric use and is produced under an ISO 13485 quality system.COMMACK, NY
NerveSpaAkron-based NerveSpa makes provider-guided therapeutic devices and care protocols centered on neuropathy, nerve support, joint mobility, and recovery. Launched in 2018 by Pain Management Technologies, a therapeutic-device manufacturer founded in 2000, the platform is designed to extend clinic care into structured home use. NerveSpa says its technologies have been implemented in more than 750 clinics and used in programs treating over 20,000 patients.AKRON, OH
Elite Biomedical Solutions, LLCSince 2012, Cincinnati-based Elite Biomedical Solutions has manufactured USA-made replacement components for clinical equipment while also providing biomedical equipment repair and technician training. The family-owned-and-operated company uses reverse engineering, in-house injection molding, and extensive validation to support hospital biomed departments, with its work governed by an ISO 13485:2016-certified quality system and FDA registration.CINCINNATI, OH
COSMIICCleveland’s COSMIIC grows out of a research program that has developed implantable devices since the 1960s, including the first spinal cord stimulator implanted in Cleveland in 1967. Today, it is an open-source community making the Networked Neuroprosthesis available to researchers and startups pursuing neuromodulation studies, from animal work to early human research.CLEVELAND HEIGHTS, OH