Baltimore-based THERMO-REG Inc. develops wearable thermoregulation systems that help people stay cool in extreme environments, including climate-controlled headgear for work and military use. Its in-house research focuses on reducing heat-related illness through mechanical and algorithmic heat management, with technology that captures metabolic heat and humidity from the scalp. The company reports four granted patents and one pending, and also licenses its technology or manufactures components for integration into other products.