Spun out of the nonprofit Caring Cross, Vector BioMed develops and manufactures lentiviral vectors for gene and cell therapy programs. Its LENTIVERSE™ platform combines custom vector engineering with ready-to-deploy solutions for CAR-T manufacturing, using a platform-based approach intended to shorten the path from concept to clinic. The Gaithersburg public benefit corporation pairs decades of lentiviral experience with a focus on transparent economics and expanding access to advanced therapies worldwide.
Andelyn BiosciencesBorn from decades of gene-therapy research at Nationwide Children’s Hospital, Columbus-based Andelyn Biosciences is a contract development and manufacturing organization that develops and produces viral vectors and plasmids for cell and gene therapies. Spun out as an independent company in January 2020, Andelyn carries a patient-centered origin story into work spanning early development through clinical and commercial manufacturing. Its two Ohio facilities support a record that includes more than 500 cGMP clinical batches and the production experience behind an FDA-approved systemic gene therapy.COLUMBUS, OH
Krystal Biotech, IncPittsburgh-based Krystal Biotech develops and commercializes redosable genetic medicines for rare diseases, using an engineered HSV-1 vector platform designed for focal, minimally invasive gene delivery. Its first commercial product, VYJUVEK®, is the first and only redosable gene therapy for dystrophic epidermolysis bullosa, while two U.S. GMP facilities—including a roughly 155,000-square-foot ASTRA site—support manufacturing and pipeline development. Krystal is fully integrated across vector design, gene therapy manufacturing and commercialization.325412PITTSBURGH, PA
Patheon pharma services (Thermo Fisher Scientific)Patheon Pharma Services is the pharmaceutical services business of Thermo Fisher Scientific, known for more than two decades of viral-vector development and manufacturing experience. It helps biotech and pharmaceutical developers move medicines from early development through clinical trials and commercial production, with specialized work in mRNA and gene-therapy programs.ALLENTOWN, PA
Advanced BioScience Laboratories (ABL), IncFrom its Rockville base, Advanced BioScience Laboratories (ABL) develops and manufactures viral products for vaccines, gene therapies, oncolytic therapies and immunotherapies as a contract development and manufacturing organization. ABL brings more than 60 years of experience working with industry, government and academic partners, including over 30 years focused on viral-vector development and GMP production. Its Rockville facility is ISO 9001 accredited for viral drug-substance and aseptically prepared drug-product manufacturing, and the company has translated more than 100 processes from the laboratory bench into GMP suites.POTOMAC, MD