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PA
Family-owned Interstate Sign Products grew from Ontario, Ohio, Fire Chief Jack Spangler’s firsthand experience with emergency calls delayed by hard-to-see house numbers. The company supplies reflective address signs to emergency services and communities nationwide, helping responders identify properties quickly in darkness or poor weather.
Known for bringing engineering and production together in the Pittsburgh region, Intervala is a U.S. electronics manufacturing partner for complex products. It works with medical, aerospace and defense, industrial, and data-center customers whose programs require documented quality and dependable performance. The company also operates a manufacturing site in Greater Boston and maintains AS9100D, ISO 9001:2015, and ISO 13485:2016 certifications.
Founded in 1987, Intigral manufactures residential glass for window and door manufacturers, building on a history of developing insulating-glass technologies and manufacturing processes. The company produces glass solutions such as insulating glass units and integrated blinds-between-glass, and supports manufacturers with fabrication and ongoing product-program collaboration.
Intra lighting d.o.o. designs and manufactures architectural luminaires that help shape comfortable, purposeful spaces. Its Slovenian-made portfolio is particularly distinctive for combining lighting with acoustic design, as in its Trenza and Voyd systems, while serving projects ranging from offices and hospitality venues to museums and airports. The company offers a seven-year warranty, and its manufacturing is described as ISO-certified across a 24,000-square-metre operation.
Founded in 1991 in a garage by two brothers-in-law, Invent Medical develops and 3D-prints custom orthotic and prosthetic devices for clinics and hospitals. The independent, family-owned company has evolved from traditional plaster fabrication into a digital O&P operation, using workflows it has refined since adopting 3D printing in 2010. Invent Medical fabricates devices in the United States and operates across eight countries, serving more than 1,000 clinics and hospitals in 40 countries; its devices are developed with patient trials and produced under ISO 13485 certification.
Now in its 26th year, Inverter Systems, Inc. is a Pennsylvania company known for concentrating exclusively on emergency lighting infrastructure rather than operating as a general lighting supplier. It supports customers nationwide with UL 924-listed emergency lighting inverters, helping make systems easier to specify, install, and maintain.
Founded in 1999 by Stephen Grot, Ion Power, Inc. develops, manufactures, and distributes Nafion™-based materials for electrochemical applications, including fuel-cell membrane electrode assemblies and water-electrolysis membranes. The Tyrone company is also Chemours’ sole authorized distributor of Nafion™ materials and supports customers through application-focused research, custom membrane work, and recycled Nafion™ initiatives. Its history is closely tied to Nafion’s origins: Grot’s father, Dr. Walther Grot, spent nearly four decades at DuPont and is widely credited with finding applications for the polymer.
Founded in 2018 by Sangui Wang and Vesentini Lorenzo, IoTT Innovations of China develops and distributes connected electronics for European customers, spanning connectivity, smart-home and building automation, and consumer devices. The company bridges Wang’s 15-plus years in testing and certifying Chinese-made electronics with Lorenzo’s 15-plus years of European market experience, inspecting and market-testing products before arranging distribution and after-sales support. Its offerings include specialized products such as an ATEX-certified smart padlock and a smartwatch with integrated earbuds.
Iovance Biotherapeutics develops and manufactures personalized tumor-infiltrating lymphocyte (TIL) cell therapies for people with cancer. Its 136,000-square-foot Iovance Cell Therapy Center in Philadelphia makes TIL therapy using proprietary processes, including a 22-day Gen 2 process; the company also markets Amtagvi and Proleukin.
Pennsylvania-based IPD Products, Inc. develops active air-sterilization systems that use its PlasmaFence™ cold-plasma technology to destroy or neutralize airborne pathogens. The company began in a small incubator focused on developing plasma energy technology and is now led by engineers and scientists with patents spanning high-energy physics, chemistry, and applications aimed at improving health outcomes.
With more than 30 years of experience, IPG’s Engineered Coated Products division is known for developing protective coated fabrics for demanding custom applications. The Sarasota-headquartered company serves customers worldwide while its Chicago manufacturing facility has earned TRUE Gold zero-waste certification after diverting 91.6% of its waste from landfill.
iPrint and Ship produces branded apparel, promotional merchandise and printed materials, then can pick, pack and ship those products for customers worldwide. Its distinctive reach extends beyond printing: the company sources or develops private-label products and integrates fulfillment with e-commerce platforms and CRMs. For self-published authors, it also handles book production and order fulfillment without requiring them to stock inventory.
Nearly eight decades in thermal processing have made Ipsen known for building industrial heat-treating equipment that manufacturers can keep in service for the long haul. The company supports production operations worldwide, with more than 10,000 installations and a 600-plus-person team behind its equipment and ongoing customer support.
With roots in a 1988 MOCVD operation in Cardiff, IQE plc makes advanced compound-semiconductor epiwafers and substrates that form the materials foundation of modern chips and devices. The company is the world’s only pure-play epitaxy provider with manufacturing sites across three continents, supplying technologies for connectivity, sensing, power and displays. Its facilities are independently certified to ISO 9001, ISO 14001 and ISO 45001, with experience supporting demanding automotive and aerospace requirements.
From a single kettle beside the Middleswarth family home in Beavertown, Pennsylvania, Bob Middleswarth built a potato-chip company that has been making Middleswarth Potato Chips since 1942. Ira Middleswarth & Son, Inc. remains family-operated from its Middleburg plant, where about 90 employees produce roughly 3,400 pounds of chips an hour. Known locally as Middleswarth Potato Chips, the company distributes throughout Pennsylvania and ships its snacks around the world.
Founded in 1994 under the parent company IRIS Ohyama of Japan, IRIS USA manufactures and sells consumer goods, and says it was the first company to introduce clear plastic storage containers to the U.S. market. It operates four U.S. factories, with manufacturing and distribution facilities in Surprise, Arizona; Pleasant Prairie, Wisconsin; Mesquite, Texas; and Hazleton, Pennsylvania.
From its Pennsylvania fabrication operations, family-owned Iron City Supply builds heavy-duty conveyors, radial stackers and bulk material handling equipment for mining, recycling, construction and related industries. With more than 40 years of experience, the company pairs custom engineering and plant-layout support with a rotating inventory of used processing equipment, while emphasizing made-in-USA fabrication and average lead times of two to 10 weeks. It serves customers across the United States and internationally.
Iron Star Roasting Company is the roastery and wholesale division of a Pittsburgh coffee business that began in 1993 as The Coffee Tree Roasters, a small coffee shop with an in-store roaster. The company continues to roast coffee using its original small-batch roaster alongside a Loring Smart Roaster and is operated by Jean Swoope. It identifies as a Certified Woman Owned Small Business and says it supplies single-farm-sourced coffees from around the world.
Ironmark is a marketing company that connects commercial printing and other physical campaigns with digital strategy, data, and execution under one roof. Founded in 1955 as Frank Gumpert Printing, it has evolved into a multi-location and franchise marketing partner with particular experience coordinating consistent, localized campaigns across hundreds of locations. Under second-generation CEO Jeff Ostenso, Ironmark also operates Ignition, an AI-powered platform for brand control, campaign activation, and revenue-level marketing measurement.
Founded in the mid-1990s to support off-grid installations, Hayward-based IronRidge designs and manufactures structural hardware for residential and commercial solar systems. Its roof, flat-roof and ground-mount platforms grew from an early steel-pole solar attachment into systems supporting hundreds of megawatts, with products tested for extreme conditions and backed by an ISO 9001-certified quality system. IronRidge has operated as an Enstall company since 2019 while retaining its own team and product lines.