Barrière Inc. makes science-backed wellness patches that deliver vitamins and other ingredients through the skin, offering a peel-and-stick alternative to pills and liquids. Co-founders Cleo and Alexa developed the company after Cleo found conventional transdermal patches irritating and impractical, and the brand now produces plant-powered, micronized formulas in a cGMP-compliant U.K. facility registered with the M.H.R.A. Its patches are designed to fit everyday routines, with offerings such as NAD+ Youth Repair and the vitamin D3 and K2 Hello Sunshine patch.
M.H.R.A. Registered
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ISO 9001
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cGMP-Compliant Facility
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ISO 17025 Accredited Testing Laboratory
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BytoxSince 2011, Bytox has made USA-produced wellness patches, best known for its hangover patch that delivers vitamins and nutrients through the skin while customers drink and sleep. The company has expanded that patch-based approach into daily immune and collagen support, alongside clinician-reviewed supplements such as its non-dairy probiotic formula.BROOKLYN, NY
AdCalSince 2002, AdCal has grown from two adhesive entrepreneurs working in a garage into a Brunswick, Ohio contract manufacturer focused entirely on nutritional support patches. Its 22,500-square-foot cGMP-compliant facility combines on-site formulators, chemists, and laboratory testing with scalable production for branded patches. AdCal produces millions of patches for major brands, including printed formats that go beyond the generic white sticker.BRUNSWICK, OH
Stick2HopeFounded around Mike Chiodo’s lived experience managing type 1 diabetes for three decades, Stick2Hope makes adhesive overlay and underlay patches for wearable diabetes devices. Its patches are designed to add a breathable, water-resistant layer of support while turning devices such as CGMs and insulin pumps into opportunities for personal expression, with styles ranging from seasonal themes to faith-inspired designs. The company also offers sensitive-skin options and device-specific fits, including patches for Dexcom, Libre, Medtronic and Omnipod systems.WEST POINT, PA
FrowniesBorn from a mother-daughter invention in 1889, Frownies makes its signature facial patches along with complementary skincare designed to smooth and care for expression-prone skin. The woman-owned company remains in its fifth generation, and its Dayton, Ohio team handcrafts small batches of products such as its Bulgarian rose hydrosol spray. Frownies’ original patches use a water-activated adhesive that hardens to hold skin relaxed and flat, a distinctive approach the brand says predates injectable wrinkle treatments.DAYTON, OH