Since 2011, Bytox has made USA-produced wellness patches, best known for its hangover patch that delivers vitamins and nutrients through the skin while customers drink and sleep. The company has expanded that patch-based approach into daily immune and collagen support, alongside clinician-reviewed supplements such as its non-dairy probiotic formula.
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Barrière IncBarrière Inc. makes science-backed wellness patches that deliver vitamins and other ingredients through the skin, offering a peel-and-stick alternative to pills and liquids. Co-founders Cleo and Alexa developed the company after Cleo found conventional transdermal patches irritating and impractical, and the brand now produces plant-powered, micronized formulas in a cGMP-compliant U.K. facility registered with the M.H.R.A. Its patches are designed to fit everyday routines, with offerings such as NAD+ Youth Repair and the vitamin D3 and K2 Hello Sunshine patch.
Dr. WellMe Nutritions IncDr. WellMe Nutritions Inc. develops and sells Made-in-USA vitamins, supplements and nootropics for everyday wellness, including targeted formulas such as its PregWell prenatal and Probiolise probiotic capsules. Based in Congers, New York, the company says its products are manufactured at GMP-approved sites, with every batch tested by its quality-control team for purity and quality. Its range is organized around health needs from bone and brain support to pediatric and men’s wellness, and the company also highlights experience with international market documentation and export.NY 10920, NY
RejuviaRejuvia is a family-founded wellness company making sublingual oral sprays for sleep, stress support, and daily nutrition. The business began in 2019 when co-founder RC Williams developed a 13-ingredient sleep spray for his mother, and its products are now made in the USA, with each batch independently triple-lab-tested for purity and potency. Rejuvia says its sprays serve more than 300,000 customers and are designed to absorb under the tongue rather than pass through digestion.BERWYN, PA
AdCalSince 2002, AdCal has grown from two adhesive entrepreneurs working in a garage into a Brunswick, Ohio contract manufacturer focused entirely on nutritional support patches. Its 22,500-square-foot cGMP-compliant facility combines on-site formulators, chemists, and laboratory testing with scalable production for branded patches. AdCal produces millions of patches for major brands, including printed formats that go beyond the generic white sticker.BRUNSWICK, OH