Established in North Carolina in 2012, Bioventus is a Durham-based medical device company with more than 1,200 employees worldwide and operations spanning more than 50 countries. Its clinically supported treatments are designed to help patients recover from orthopedic conditions and return to active lives; in 2024, Bioventus products helped more than 1.4 million people do so.
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OrthofixFounded in 1980, Orthofix is a Lewisville, Texas-based medical technology company that develops devices and biologic solutions for spine care and limb reconstruction. Its work spans reconstructive and regenerative treatment, including bone-growth therapies and the 7D FLASH Navigation System, with products used to help patients regain mobility in more than 60 countries. Orthofix also develops biologics through its in-house tissue bank in Irvine, California, and collaborations with MTF Biologics.WAYNE, PA
East Coast Orthotic & Prosthetic CorpFounded by brothers Vincent and Lawrence Benenati in 1997, East Coast Orthotic & Prosthetic Corp. designs and manufactures custom orthotic and prosthetic devices, including its NYRC Brace with Smart Brace Technology for scoliosis care. Based in Deer Park, the family-owned company has grown to more than 240 employees and over 30 patient-care locations across the New York metropolitan area and beyond. Its in-house lab and research team use CAD/CAM manufacturing while clinicians guide patients through fitting, rehabilitation and ongoing support.DEER PARK, NY
Drive DeVilbiss HealthcareSince its founding in 2000, Drive DeVilbiss Healthcare has grown into a global medical-equipment manufacturer with offices, factories and warehouses across several continents. The company is known for building practical equipment that supports independence, serving homecare providers, long-term-care organizations and other healthcare channels in more than 100 countries.PORT WASHINGTON, NY
Synapse Biomedical IncFounded in 2002, Oberlin-based Synapse Biomedical develops and manufactures neurostimulation medical devices that help patients breathe and recover movement. Its FDA-approved NeuRx Diaphragm Pacing System supports diaphragm conditioning for people with spinal cord injuries and ALS, while the company’s TransAeris system is designed to address ventilator-induced diaphragm dysfunction. Synapse says its NeuRx products are manufactured in Ohio at an ISO 13485-certified facility and have been used to treat more than 2,000 patients.OBERLIN, OH