Brooklyn-based Caladan builds automated bioreactor systems and software for high-throughput bioprocess development. Founded by Rob Jauquet and Mike Kobida, the company combines lab automation, advanced sensing and AI-oriented data tools in its Caladan 250 benchtop platform, which is designed for rapid strain screening and process optimization. Its team aims to connect experiments from benchtop development through production scale-up in one data-driven system.
CarbonBridge IncBased in New York City’s West Harlem Innovation Cluster, CarbonBridge builds compact direct-gas bioreactors that help scientists use microbes to turn gases into industrial chemicals. Its modular platform is designed to eliminate the solubility barriers of conventional aqueous bioprocessing, while responding to process changes in under 60 seconds. CarbonBridge is also developing pathways for products such as methanol and polymer intermediates, with research collaborations supporting future scale-up.New York, NY
Trailhead BiosystemsFounded in 2015 as a Cleveland Clinic and Case Western Reserve University spinout, Trailhead Biosystems is a Beachwood biotechnology company built around the research of founder Jan Jensen. It is known for HD-DoE®, a data-driven platform that uses computational modeling and robotic experimentation to direct induced pluripotent stem cells into specialized human cells for researchers developing new medicines and cell therapies.BEACHWOOD, OH
Skellig AutomationFounded by Paul O’Sullivan in 2010, Skellig Automation designs and builds automation systems for biotechnology and pharmaceutical manufacturing. The company operates as an engineer-led systems integrator, supporting projects from staff augmentation and capital work through digital transformation and validated system execution. Skellig’s vendor-agnostic approach and SkelligDocs software reflect its focus on practical, transparent solutions for modern Life Sciences operations.DANVILLE, PA
Advanced Solutions Life Sciences, LLCFounded by Louisville engineer Michael Golway, Advanced Solutions Life Sciences develops and manufactures biofabrication equipment and software for building and studying 3D biological structures. Its flagship BioAssemblyBot is a patented six-axis bioprinting platform, supported by automation software and Angiomics human microvessels for vascularized tissue models. The ASI subsidiary operates from a 15,000-square-foot Louisville facility with more than 50 engineers and technical professionals, alongside a biomedical research laboratory in Manchester, New Hampshire.PHILADELPHIA, PA