Calvary Spine designs, manufactures, and distributes FDA-cleared interbody fusion devices made from PEEK-OPTIMA polymer, with lumbar and cervical spacers intended to support spinal fusion and restore disc height. Based in Baltimore, the company differentiates itself by pairing surgeon-designed implants and instruments with annual price guarantees that it says run 30%–50% below typical market pricing. Its service model includes next-day delivery, loaner instruments, and exchanges for unused inventory.
FDA cleared
Compliance program
CE-marked
FDA
Quality certification
CE
Quality certification
Legend SpineLegend Spine is a spine device company focusing on delivering high quality care through superior product development and customer service. The specialized technical and medical staff continues to develop fusion, non-fusion, and specialized techniques meeting the needs of the spine market. With a lean work force mentality and more than 40 years of spine device knowledge, the company has the ability to move quickly to the market and client demands.LANGHORNE, PA
Altus SpineAltus Spine develops and manufactures medical devices for spinal correction surgery, pairing surgeon collaboration with in-house engineering and manufacturing in its West Chester, Pennsylvania plant. Its systems include the Sochi occiput-to-sacrum platform and the Brickyard ALIF system, with design emphasis on streamlined instrumentation and rapid response to clinical needs. The company operates under ISO 13485 regulatory requirements and has received FDA 510(k) clearances for products including Sochi and Monaco HA.WEST CHESTER, PA
Centinel SpineWith roots in the first prodisc implantation in 1990, Centinel Spine develops and manufactures cervical and lumbar total disc replacement devices for motion-preserving spine surgery. The West Chester company’s prodisc platform has been used in more than 300,000 implantations worldwide over 35 years, and its Match-the-Disc portfolio lets surgeons select among implant designs for patient anatomy and surgical preference. In 2025, its prodisc C Vivo and prodisc C SK systems became the first two different cervical devices approved in the United States for both one- and two-level use.WEST CHESTER, PA
Camber Spine Technologies, LLCCamber Spine Technologies develops surgeon-designed medical devices for minimally invasive and minimally disruptive treatment of complex spinal conditions. Based just outside Philadelphia, the company combines 3D printing with its ENZA® and SPIRA® implant platforms and has developed a patented OLIF system for oblique access to the lumbar spine. Its 27,000-square-foot facility includes a mechanical test lab, prototype shop and double cadaver lab, and the company is an ISO 13485-certified medical device manufacturer.KING OF PRUSSIA, PA