With roots in the first prodisc implantation in 1990, Centinel Spine develops and manufactures cervical and lumbar total disc replacement devices for motion-preserving spine surgery. The West Chester company’s prodisc platform has been used in more than 300,000 implantations worldwide over 35 years, and its Match-the-Disc portfolio lets surgeons select among implant designs for patient anatomy and surgical preference. In 2025, its prodisc C Vivo and prodisc C SK systems became the first two different cervical devices approved in the United States for both one- and two-level use.
Corporate Compliance Program
Compliance program
California Comprehensive Compliance Program
Compliance program
Altus SpineAltus Spine develops and manufactures medical devices for spinal correction surgery, pairing surgeon collaboration with in-house engineering and manufacturing in its West Chester, Pennsylvania plant. Its systems include the Sochi occiput-to-sacrum platform and the Brickyard ALIF system, with design emphasis on streamlined instrumentation and rapid response to clinical needs. The company operates under ISO 13485 regulatory requirements and has received FDA 510(k) clearances for products including Sochi and Monaco HA.WEST CHESTER, PA
Calvary Spine, LLCCalvary Spine designs, manufactures, and distributes FDA-cleared interbody fusion devices made from PEEK-OPTIMA polymer, with lumbar and cervical spacers intended to support spinal fusion and restore disc height. Based in Baltimore, the company differentiates itself by pairing surgeon-designed implants and instruments with annual price guarantees that it says run 30%–50% below typical market pricing. Its service model includes next-day delivery, loaner instruments, and exchanges for unused inventory.LUTHERVILLE, MD
ReVivo MedicalReVivo Medical develops spinal-surgery implants, with its CEM-Plate and CEM-Cage currently under investigation in an FDA-sanctioned first-in-human clinical trial. Based in Loudonville, the company was founded by spine surgeons and biomedical researchers to improve patient outcomes while simplifying operating-room workflow and reducing implant components. Its work is backed by 18 issued U.S., European, and Canadian patents, as listed by the company.LOUDONVILLE, NY
Medicrea International SASMedicrea International SAS develops medical devices for spinal surgery, including systems for cervical and thoracolumbar applications. The company is now part of Medtronic, linking its spinal-device business to the broader Medtronic organization.New York, NY