Founded in 2006 near Pittsburgh by medical-device engineer David Groll, Circadiance develops and manufactures respiratory-care equipment and remote patient-monitoring systems. The company is best known for SleepWeaver, the first all-cloth positive-airway-pressure mask, and also supports infant and pediatric care through SmartMonitor and Synergy Cloud products. Circadiance is ISO 13485 certified and distributes its products internationally.
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Instrumentation Industries, IncSince 1967, Instrumentation Industries, Inc. has manufactured respiratory-care and other medical components in Pittsburgh, including the adapters, connectors and emergency ventilation parts used in clinical settings. The company molds plastic and silicone and fabricates metal in-house, supporting OEM customers from prototypes through production with its own tooling, machining, engineering and assembly capabilities. Its products are made in the USA, and the facility is ISO 13485:2016 certified.BETHEL PARK, PA
Respair, IncBorn from University of Pittsburgh clinical research, Pittsburgh-based Respair develops airway devices for ventilated patients, beginning with RelianceET, a breathing tube designed to replace the conventional inflatable cuff with soft baffles that seal the airway without added pressure. Founded by physicians Carl Snyderman and Garrett Coyan, the company brings surgeons, engineers, and entrepreneurs together to address ventilator-associated complications. Respair completed hundreds of benchtop tests and received a Phase I SBIR award from the NIH while advancing the device toward regulatory submission.PITTSBURGH, PA
ORICARE IncFounded in Pennsylvania in 2009, ORICARE Inc. is a U.S.-based medical-device manufacturer focused on equipment for operating rooms and intensive care units. Its products are used in hospitals internationally, with installations reported in places including Stanford Hospital and Australian hospitals. ORICARE holds ISO 13485 certification and has received FDA 510(k) clearance for an ICU ventilator.QUAKERTOWN, PA
Advanced Respiratory Technologies, Inc. (ART)Founded in 2015 by extracorporeal life-support experts, Pittsburgh-based Advanced Respiratory Technologies is developing artificial lungs and a wearable Pulmonary Assist System for long-term respiratory support. Its battery-powered, 3.2-kilogram system is designed to give people with chronic lung disease greater mobility and a path home from intensive care, while also supporting military transport. ART has produced a third-generation prototype and has received more than $22 million in grant funding during its development.339113PITTSBURGH, PA