Founded by board-certified OB/GYN Kim Langdon, Coologics is a clinical-stage medical device company developing Vlisse, a patented controlled-cooling device for the drug-free management of vaginal yeast infections. The Broadview Heights company is evaluating this non-hormonal approach in FDA-aligned clinical studies, building on published human and mouse research into symptom relief, infection biology, and inflammation. Vlisse remains investigational and is not currently available for sale.
FDA De Novo Class II medical device pathway
Compliance program
European Union Class I Device; CE Mark Pending
EUCLASSIMEDICALDEVICE
Quality certification
FEMSelectFEMSelect develops women’s-health medical devices for pelvic floor conditions, notably EnPlace, a mesh-free system for minimally invasive, same-day pelvic organ prolapse repair. The company grew from POP Medical Solutions, which began developing the technology in 2013, received FDA clearance in 2016, and changed its name to FEMSelect in 2019. FEMSelect is woman-led and also offers FDA-cleared Elitone devices for at-home urinary-incontinence treatment.MANHATTAN, NY
Upsilon Healthcare TechnologiesFounded by Antonella Sturniolo, Upsilon Healthcare Technologies develops reproductive-health technology centered on the Upsilon IUD, a proposed hormone-, copper-, metal- and plastic-free contraceptive device designed to conform to the uterus. Sturniolo was inspired by her grandfather, OB/GYN Dr. Soichet, who invented the Ypsilon IUD in the 1960s and saw it used globally until 1982. The New York-based, female-founded company brings together researchers, scientists and executives focused on addressing gaps in women’s reproductive healthcare, with the device’s stated benefits still pending clinical validation and FDA review.541715WYNNEWOOD, PA
PlaygroundPlayground makes clinically tested, hormone-free intimate wellness products for women, including vaginal hydration inserts and water-based lubricants. Co-founded by Catherine Magee, Christina Aguilera, and Sandy Vukovic, the brand pairs product development and women’s health expertise with a clinical team led by a board-certified OB/GYN. Its products are made in the USA, and the company says they are available in more than 1,500 store locations and recommended by over 500 healthcare providers.NEW YORK, NY
YarlapCo-founded by daughter MaryEllen Reider and her father Brent, Yarlap makes an FDA-cleared pelvic-floor exercise device designed to perform Kegel workouts for women. The USA-based company combines Brent’s bio-mimicry electrostimulation expertise with MaryEllen’s focus on accessible, stigma-free pelvic-floor wellness, and its device is manufactured in Ireland.OXFORD, OH