Founded in 2008 in Cleveland, Ohio, Cryothermic Systems develops medical devices that cool the body rapidly and noninvasively, led by its Cryo Cooling System for targeted temperature management. Its activated cooling packs reach -5°C in seconds and are designed to start cooling in the field before patients reach emergency, cardiac, or intensive care. The company was founded by Harvard-trained cardiothoracic surgeon Aqeel Sandhu and was formerly known as Life Core Technologies.
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NeuroIntact, IncFounded in April 2023 by Bryan Nicholson, Baltimore-based NeuroIntact develops precision temperature-modulation devices for hospitalized patients. Its VCool™ system uses noninvasive intranasal technology to cool or warm the core body, weighing about 22 pounds and mounting to a standard IV pole rather than relying on bulky conventional consoles. The company’s first-in-human study demonstrated measurable cooling in awake participants without adjunctive pharmaceuticals.BALTIMORE, MD
Grimm Scientific Industries, IncJoe Grimm founded Grimm Scientific Industries after bringing his experience developing temperature-controlled medical devices to sports medicine in 1983. Based in Marietta, Ohio, the company designs and manufactures hydrotherapy systems for athletes and athletic trainers, including its CRYOTherm line, and supports those systems with factory service.MARIETTA, OH
Hybernia Medical, INCFounded and managed since 2006 by physicians and inventors, Hybernia Medical develops endovascular medical technology for selectively cooling the brain during acute ischemic stroke treatment. The Mineola company’s patented Delta-H Cooling Technology is designed to deliver rapid, controlled hypothermic protection through the same arterial access used for endovascular stroke care. Originally spun off from Columbia University, Hybernia is a clinical-development-stage company whose technology has advanced from bench engineering to preclinical testing and a first-in-human study.UNIONDALE, NY
CPSI BiotechFounded by cryomedicine researcher John M. Baust, Ph.D., CPSI Biotech is an Owego technology-development company creating investigational cryo-medical devices and life-science research products. Its work combines cryobiology with medical-device engineering for applications in cancer treatment, cardiovascular care, and cell-therapy bioprocessing. CPSI’s pipeline includes more than 10 prototype devices, which it advances toward commercialization through partnerships, licensing, and contract research.OWEGO, NY