Hemoglobin Oxygen Therapeutics develops human and veterinary hemoglobin-based oxygen carriers that increase blood’s ability to transport oxygen. Its Hemopure product is used in South Africa and Russia for acute anemia and remains investigational in the United States, while Oxyglobin was the first veterinary oxygen therapeutic approved in the US and Europe for canine anemia. The company draws on more than 25 years of research and has consolidated production at a facility in Souderton, Pennsylvania, undergoing a multimillion-dollar expansion.
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Globin SolutionsFounded by University of Pittsburgh physician-scientists in 2017, Globin Solutions develops recombinant heme-protein therapeutics, including candidates intended to counter carbon monoxide poisoning. The Baltimore company’s proprietary yeast-based platform produces complex heme proteins at more than 95% purity and also supports research into artificial blood substitutes. Its neuroglobin candidate has received FDA Orphan Drug Designation, while the company advances three therapeutic programs toward clinical development.325414PITTSBURGH, PA
OxyDialFounded by Olek Shestakov and Alex Aprelev, OxyDial develops an Oxygen-Hemoglobin Equilibrium blood-testing instrument and cloud platform for medical researchers and healthcare providers. The company’s work is aimed particularly at improving understanding and care for sickle cell disease and other blood disorders, with the instrument and services still under development and testing and not yet FDA-approved. Its founders bring more than 25 years of experience spanning software architecture, wearables, IoT devices, optics and spectroscopy.PHILADELPHIA, PA
Inogen, IncSince 2001, Inogen has developed and makes portable oxygen concentrators for people receiving respiratory therapy, with its pulse-dose systems designed for use beyond the home. The company says it has sold or rented more than one million units worldwide and distributes its concentrators through international partners in more than 59 countries. Its current product line includes the Inogen One G5 and the newer Rove systems, supported by published clinical research and a focus on extending device service life.BROOKLYN, OH
OxygeniumBorn from combat-medicine experience and an emergency physician’s response to oxygen shortages in the field, Oxygenium develops portable medical oxygen delivery systems. Its patented technology generates continuous, adjustable high-flow oxygen on demand through a chemical cartridge system, offering an alternative to explosive cylinders and power-dependent concentrators. The New York company was founded by trauma surgeon and former IDF combat physician Dr. Ben Alkahe with Ran Miron.New York, NY