Since 2001, Inogen has developed and makes portable oxygen concentrators for people receiving respiratory therapy, with its pulse-dose systems designed for use beyond the home. The company says it has sold or rented more than one million units worldwide and distributes its concentrators through international partners in more than 59 countries. Its current product line includes the Inogen One G5 and the newer Rove systems, supported by published clinical research and a focus on extending device service life.
OxygeniumBorn from combat-medicine experience and an emergency physician’s response to oxygen shortages in the field, Oxygenium develops portable medical oxygen delivery systems. Its patented technology generates continuous, adjustable high-flow oxygen on demand through a chemical cartridge system, offering an alternative to explosive cylinders and power-dependent concentrators. The New York company was founded by trauma surgeon and former IDF combat physician Dr. Ben Alkahe with Ran Miron.New York, NY
CAIRE IncFor more than 50 years, CAIRE Inc. has built its identity around oxygen, developing delivery equipment for people who rely on respiratory care and for commercial users who generate gas onsite. Headquartered in Ball Ground, Georgia, the company became part of Japan’s Niterra in 2018 and continues that oxygen-focused work through its medical and AirSep commercial operations.BUFFALO, NY
Beyond Air, IncBeyond Air develops medical devices for inhaled nitric oxide therapy, with its LungFit systems generating nitric oxide on demand from room air for use from hospital to home. The company’s technology team includes inventors behind the first FDA-cleared nitric oxide delivery system, giving its current platform a direct link to the commercialization of inhaled nitric oxide therapy. Its work also emphasizes reducing the cylinders, chemicals, transport, and energy demands associated with conventional nitric oxide delivery.GARDEN CITY, NY
Rhythm Healthcare, LLCRhythm Healthcare, formerly Lifestyle Mobility Aids, makes respiratory and durable medical equipment for care delivered at home, with portable and stationary oxygen concentrators at the center of its business. Founded in 1992, the company has grown from its mobility-aids roots into a provider-focused operation with a 60,000-square-foot distribution center in Atlanta and international operations launched in 2025. Its Rhythm Resolve program replaces qualifying oxygen equipment with brand-new units and offers zero-dollar exchanges, reflecting a distinctive focus on reducing disruption for HME providers and their patients.New York, NY