Built around an antibody platform derived from the densely packed coat of the African trypanosome, Hepione Therapeutics develops immunotherapeutics aimed at preventing opioid overdoses. The Manhattan biotech startup’s lead program uses VAST and its Hyper Speed selection process to identify monoclonal antibodies that bind fentanyl and block its passage to the brain; preclinical studies reported protection from near-lethal fentanyl exposure. The underlying platform originated in Dr. Nina Papavasiliou’s laboratory in 2008 and has been developed across two continents.
NIH SBIR Award
Compliance program
Emergent BioSolutionsEmergent BioSolutions is a public health company that develops and manufactures protective medicines and medical countermeasures for opioid overdose emergencies and biological threats. Founded in 1998, it began by partnering with the U.S. government to supply an anthrax vaccine and now operates manufacturing facilities across the United States and Canada, alongside research and development and commercial product operations.325412PLYMOUTH MEETING, PA
Emergent BioSolutionsFounded in 1998 through a partnership with the U.S. government to supply an anthrax vaccine, Emergent BioSolutions develops, manufactures and delivers medical countermeasures and other protective products for public-health emergencies. The company has spent more than 25 years preparing governments and communities for biological threats, while also expanding access to naloxone for opioid-overdose response. Emergent also operates four North American manufacturing facilities and partners with biopharma innovators on complex development and manufacturing work.GAITHERSBURG, MD
Emergent BioSolutionsFounded in 1998 to supply the U.S. government with anthrax vaccine, Emergent BioSolutions develops and manufactures medical countermeasures and other protective products for biological threats and opioid overdose emergencies. The company also operates as a strategic manufacturing partner, using specialized containment capabilities across four North American facilities to help biopharma companies, governments and nonprofits develop and make complex biological products. Its commercial portfolio includes NARCAN® Nasal Spray alongside preparedness products for threats such as anthrax, smallpox and botulism.ROCKVILLE, MD
Resilient LifescienceFounded in Pittsburgh in April 2022, Resilient Lifescience is developing a wearable medical device intended to detect and automatically reverse opioid overdoses. Its Resilient System uses non-invasive sensing to identify opioid-induced respiratory depression, sound an alarm, and deliver naloxone, with prototype testing underway in Pittsburgh and Philadelphia. The company was created by Brad Holden, a former Marine Corps officer with medical-device experience, and software engineer Charlie Proctor to address overdoses that often happen when no bystander is present.PITTSBURGH, PA