Hsiri Therapeutics is a biotechnology company developing therapies for infections caused by drug-resistant bacteria and fungi, with particular attention to tuberculosis and nontuberculous mycobacterial disease. Its discovery work originated at the University of Notre Dame and Montana State University, and its research laboratories are in South Bend, Indiana, alongside collaborations in Montana and Singapore. The company has received support from the Department of Defense and the National Institutes of Health and has entered research and licensing collaborations with Shionogi.