Cleveland-based Neuronoff develops and manufactures the investigational Injectrode, a needle-delivered neuromodulation device designed to make chronic-pain treatment less invasive than conventional implanted stimulators. Its system is placed through an 18-gauge needle, powered externally through the skin, and designed for straightforward removal; the company has completed its first-in-human LIFE study and reports Technology Readiness Level 7 for lower-back pain applications. Neuronoff manufactures in Cleveland under ISO 13485 and MDSAP-certified quality systems, while researching applications beyond pain care.
ISO 13485
MDSAP (Medical Device Single Audit Program)
ISO 14971 Risk Management Process
Compliance program
COSMIICCleveland’s COSMIIC grows out of a research program that has developed implantable devices since the 1960s, including the first spinal cord stimulator implanted in Cleveland in 1967. Today, it is an open-source community making the Networked Neuroprosthesis available to researchers and startups pursuing neuromodulation studies, from animal work to early human research.CLEVELAND HEIGHTS, OH
ReBuilder Medical, IncReBuilder Medical develops the ReBuilder®, a prescription, FDA-cleared electrical stimulation device for at-home management of neuropathy and other chronic pain. Inventor and founder David B. Phillips created the original system for his father more than 30 years ago, and the company has continued producing and updating it since 1988. Based in Charles Town, West Virginia, ReBuilder Medical also supports physicians and veterans using the device in clinical and home-care settings.CHARLES TOWN, WV
NerveSpaAkron-based NerveSpa makes provider-guided therapeutic devices and care protocols centered on neuropathy, nerve support, joint mobility, and recovery. Launched in 2018 by Pain Management Technologies, a therapeutic-device manufacturer founded in 2000, the platform is designed to extend clinic care into structured home use. NerveSpa says its technologies have been implemented in more than 750 clinics and used in programs treating over 20,000 patients.AKRON, OH
Synapse Biomedical IncFounded in 2002, Oberlin-based Synapse Biomedical develops and manufactures neurostimulation medical devices that help patients breathe and recover movement. Its FDA-approved NeuRx Diaphragm Pacing System supports diaphragm conditioning for people with spinal cord injuries and ALS, while the company’s TransAeris system is designed to address ventilator-induced diaphragm dysfunction. Synapse says its NeuRx products are manufactured in Ohio at an ISO 13485-certified facility and have been used to treat more than 2,000 patients.OBERLIN, OH