Park Perfection is a family-owned, dermatologist-owned skin-care company built around the Parks family in Columbus, Ohio. Board-certified dermatologist Dr. Alan J. Parks founded the brand after more than 30 years in dermatology, drawing on conversations with thousands of patients to develop formulas for unmet skin-care needs. His wife Robin and children Jason and Stefanie run the day-to-day business, while the products are made in the United States.
Formula 2 Skin CareA father-and-son pharmacist team gave Formula 2 Skin Care its start in Delaware in 1988, when Mark and Sam Isabella refined a cream first made for a local pharmacy customer. The family’s product, now made near Daytona Beach, Florida, is used by people and health-care providers seeking relief for severely dry or irritated skin.AVONDALE, PA
PH AdvantageFounded by plastic surgeon Dr. Barry J. Cohen, PH Advantage is a Maryland skincare brand shaped by his experience treating patients before and after cosmetic surgery. The company develops clinically documented formulas with attention to skin pH and ingredient bioavailability, including the cytokinins-based Pyranase treatment.SILVER SPRING, MD
Topix Skin HealthFounded in 1981 by Stanley and Burt Shaffer, Topix Skin Health develops and manufactures science-based skin-care products through a portfolio of professional and consumer brands. Its New York-based Topiderm operation provides in-house research, development and manufacturing, supported by more than 40 scientists, including three full-time PhD microbiologists. The company’s formulas are developed with dermatologists and physicians, with products tested by more than 6,000 physicians over four decades.AMITYVILLE, NY
DR. MACRENE activesFounded around the work of dermatologist-scientist Macrene Alexiades, MD, PhD, DR. MACRENE actives makes dermatologist-developed skincare designed to bring clinical research into everyday formulas. The New York company’s products are built around its patented MA37™ multi-active technology and plant-derived ingredients, while its Manhattan and Wainscott spas extend that approach into personalized treatments. Alexiades holds BA, MD, and PhD degrees from Harvard and is dual board-certified in dermatology in the United States and European Union.NEW YORK, NY