Founded in 2019 by physicians Ginger and Jay Constantine, PleoPharma develops pharmaceutical treatments for substance use disorders, beginning with an investigational oral therapy for cannabis withdrawal. The Phoenixville-based company emerged after the founders saw patients struggling to stop cannabis use and discovered that no effective treatment existed; its lead program, PP-01, has completed Phase 2.
Braeburn IncPlymouth Meeting-based Braeburn develops specialty pharmaceutical treatments for opioid use disorder, including BRIXADI, a buprenorphine extended-release injection. Its work extends beyond drug development into research, advocacy and community partnerships aimed at reducing stigma and improving access to recovery care, with particular attention to underserved populations.325412PLYMOUTH MEETING, PA
Axsome Therapeutics, IncFounded in January 2012 by physician Herriot Tabuteau, Axsome Therapeutics is a New York biopharmaceutical company focused on central nervous system conditions with limited treatment options. Its work centers on developing therapies intended to give patients and physicians new approaches where existing care falls short.NEW YORK, NY
PL DevelopmentsFounded in 1988 by Mitch Singer and Mort Rezack, PL Developments makes, packages and distributes store-brand over-the-counter medicines and consumer healthcare goods. Still family-owned under Singer and his sons, the company has grown from a small private-label operation into a 1,600-plus-employee business with more than 2 million square feet of pharmaceutical facilities. PLD is particularly distinctive for operating the only FDA-approved nicotine chewing-gum facility in the United States, alongside newer nutritional and OTC gummy production.WESTBURY, NY
Agronomed Pharmaceuticals LLCFounded in Chester County, Pennsylvania, Agronomed Pharmaceuticals LLC cultivates, processes, researches and supplies cannabis-based health products. The minority-owned company is operated by a team of doctors, pharmacists, pharmacologists and entrepreneurs whose work centers on developing formulations for specific medical indications and studying patient outcomes. Its Pennsylvania joint venture, Agronomed Biologics, extends that focus into cannabis product development and clinical and pre-clinical research.EXTON, PA