Plymouth Meeting-based Braeburn develops specialty pharmaceutical treatments for opioid use disorder, including BRIXADI, a buprenorphine extended-release injection. Its work extends beyond drug development into research, advocacy and community partnerships aimed at reducing stigma and improving access to recovery care, with particular attention to underserved populations.
MedicaSafeMedicaSafe develops smart medication systems that pair prescription drugs with secure, programmable dispensing devices and cloud-based monitoring. Its first product is designed for opioid use disorder, using pre-packaged buprenorphine/naloxone cartridges and a SmartKey to guide dosing, deter unauthorized access, and give clinicians real-time usage insight. The company says its patients took medication as prescribed on 97% of days in reported results, compared with 72% for a reference treatment-as-usual group.NEW YORK, NY
Egalet CorporationEgalet Corporation is a fully integrated specialty pharmaceutical company developing and commercializing medicines for acute and chronic pain, with a particular focus on oral products designed to deter prescription-drug abuse. Its Guardian Technology uses physical and chemical barriers alongside tailored drug release, while the company’s manufacturing approach combines pharmaceutical production with plastic injection molding. Egalet has marketed OXAYDO and SPRIX and has described late-stage abuse-deterrent opioid candidates in its pipeline.WAYNE, PA
PleoPharma, IncFounded in 2019 by physicians Ginger and Jay Constantine, PleoPharma develops pharmaceutical treatments for substance use disorders, beginning with an investigational oral therapy for cannabis withdrawal. The Phoenixville-based company emerged after the founders saw patients struggling to stop cannabis use and discovered that no effective treatment existed; its lead program, PP-01, has completed Phase 2.PHOENIXVILLE, PA
PGRrxPGRrx is a 503B pharmaceutical outsourcing facility that produces sterile and non-sterile compounded medicines to help healthcare providers navigate drug shortages and tailor dosage forms to patient needs. Founded by pharmacist Amit Gupta, the company also supports CMC and clinical-trial research, drawing on his experience leading sterile and non-sterile compounding in inpatient institutions. Its work is organized around supplying safe, personalized pharmaceutical access to communities facing gaps in availability.EXTON, PA