Founded in 2017 out of the University of Pittsburgh and Cornell University, Pittsburgh-based Renerva develops implantable medical devices and biomaterials for peripheral nerve injury, including its investigational PNM-CAP nerve-capping device for neuroma pain. The company’s research centers on decellularized porcine nerve extracellular matrix, with products intended to help limit painful nerve growth or support nerve recovery; its technologies are not yet commercially available. Renerva operates from Pittsburgh with a satellite location in Ithaca, New York.
Checkpoint Surgical IncCheckpoint Surgical develops medical devices and biomaterials for peripheral nerve surgery, helping surgeons assess, protect, prepare and repair nerves during operations. Based in Independence, Ohio, the company pairs its nerve-care product portfolio with Nerve Master educational programs, surgeon partnerships and clinical studies investigating electrical stimulation to improve nerve healing. Its work spans intraoperative decision-making through nerve repair and restoration.INDEPENDENCE, OH
SensarsSensars develops implantable neuroprosthetic and neurostimulation systems designed to restore protective sensation in people with diabetic neuropathy and limb loss. Its SENSY platform combines nerve-implanted electrodes with smart wearable insoles, and preliminary human trials have demonstrated sensory restoration, improved gait and reduced pain. The Swiss-founded company’s work has appeared in more than 25 peer-reviewed publications and received FDA Breakthrough Device Designation.
ReBuilder Medical, IncReBuilder Medical develops the ReBuilder®, a prescription, FDA-cleared electrical stimulation device for at-home management of neuropathy and other chronic pain. Inventor and founder David B. Phillips created the original system for his father more than 30 years ago, and the company has continued producing and updating it since 1988. Based in Charles Town, West Virginia, ReBuilder Medical also supports physicians and veterans using the device in clinical and home-care settings.CHARLES TOWN, WV
Neoolife, IncPittsburgh-based Neoolife, Inc. is a pre-clinical Bio-MedTech startup developing tissue-engineered biomimetic heart valves and cardiovascular patches designed to support the body’s own tissue regeneration. Its distinctive Double Component Deposition technology creates non-animal-derived polymeric scaffolds, including the OneValveTric transcatheter tricuspid valve system, while the company’s international team brings more than 130 years of combined biomedical and cardiovascular experience. The technology has received support through NIH and European Research Council grants, but Neoolife’s products remain in research and pre-clinical development and are not yet approved by regulators.PITTSBURGH, PA