Rockville-based Rise Therapeutics develops oral immunotherapies that use synthetic biology to target dendritic cells and recalibrate immune responses in autoimmune disease and cancer. The clinical-stage company pairs its proprietary oral delivery platform with in-house clinical GMP manufacturing, taking candidates from discovery through human clinical validation. Its pipeline includes oral programs for ulcerative colitis, rheumatoid arthritis, and cancer.
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Innovative Cellular TherapeuticsHeadquartered in Rockville, Innovative Cellular Therapeutics is a private clinical-stage biotechnology company developing cellular immunotherapies for solid tumors. Its proprietary CoupledCAR® platform underpins individually made CAR-T therapies, including the lead GCC19CART program being studied for relapsed or refractory metastatic colorectal cancer. Founded by Larry Lei Xiao and Zoe Zhao Wu, ICT combines more than 20 years of stem-cell, cell-therapy and gene-editing experience with FDA cellular-therapy review expertise.ROCKVILLE, MD
Leadiant Biosciences, IncFrom its Rockville base, Leadiant Biosciences develops and distributes prescription therapies for people living with rare diseases. The private U.S. pharmaceutical company draws on a longstanding heritage in orphan-drug development, becoming the fourth company in the world to receive a U.S. Orphan Drug Designation in 1984. Its research teams work with physicians, researchers, academic institutions and biotechnology organizations, while patient-support programs provide education and resources beyond the medicine itself.ROCKVILLE, MD
Ortek-BasicBites®Founded in 1998, Ortek Therapeutics develops oral-health technologies and makes BasicBites, sugar-free soft chews designed to support enamel and the oral microbiome. The company’s work grew from a long-running collaboration with the Research Foundation for the State University of New York and Stony Brook University School of Dental Medicine, where its arginine bicarbonate and calcium carbonate technology was developed and clinically tested. Ortek also created the FDA-cleared Ortek-ECD device for early detection of occlusal cavities, while BasicBites brings its microbiome research into a daily consumer product manufactured in the United States at an FDA-registered, CGMP facility.ROSLYN HEIGHTS, NY
Rose BioSolutionsRose BioSolutions is an advanced therapy CDMO providing human immune and stem cells, biospecimens, plasmid DNA, viral vectors, and cell therapy manufacturing. Its integrated capabilities support research, process development, clinical manufacturing, and commercial production.