Founded in 1998, Ortek Therapeutics develops oral-health technologies and makes BasicBites, sugar-free soft chews designed to support enamel and the oral microbiome. The company’s work grew from a long-running collaboration with the Research Foundation for the State University of New York and Stony Brook University School of Dental Medicine, where its arginine bicarbonate and calcium carbonate technology was developed and clinically tested. Ortek also created the FDA-cleared Ortek-ECD device for early detection of occlusal cavities, while BasicBites brings its microbiome research into a daily consumer product manufactured in the United States at an FDA-registered, CGMP facility.
FDA-Registered Manufacturing Facility
registration
Current Good Manufacturing Practices (CGMP)
compliance_program
RiseWellFounded in 2017 by John and Kori Estrada with Kori’s brother, dentist and prosthodontist Dr. Derek Gatta, RiseWell makes family-friendly oral-care products powered by hydroxyapatite. The company grew from the founders’ search for a clean alternative that would support enamel as well as remove unwanted ingredients, and its dentist-developed formulas are designed to be safe to swallow and backed by clinical science. RiseWell’s product line includes its signature and higher-concentration PRO mineral toothpastes for everyday family care and greater sensitivity needs.
Oralmega ManufacturingOralmega Manufacturing makes custom-branded teeth-whitening and oral-wellness products for companies building their own brands. Its U.S.-made formulations and kits can be ordered in low quantities—as few as 10 units for some customized kits—while the company also provides product development, production, fulfillment, and regulatory guidance. Oralmega says it has done business in more than 30 countries and brings over 30 years of combined whitening and oral-wellness experience to its partners.TONAWANDA, NY
Biolectrics LLCBiolectrics LLC develops OraFlow, a personal mouthpiece designed for periodontal therapy. Based in Rocky River, Ohio, the company focuses on a smart, home-oriented approach to oral care.CLEVELAND, OH
Kaylaan LLCFounded by engineer Deepti Brambl and toxicologist Wells Brambl, Kaylaan makes toothpaste tablets and other plastic-free oral-care products at its FDA-compliant manufacturing plant in New York. The woman-owned, certified B Corporation developed its tablets during the pandemic as a cleaner alternative to conventional toothpaste tubes, packaging them in reusable tins with compostable refills. Kaylaan says its products have diverted more than 100,000 toothpaste tubes from landfills.FLORAL PARK, NY