Founded in 2017 by John and Kori Estrada with Kori’s brother, dentist and prosthodontist Dr. Derek Gatta, RiseWell makes family-friendly oral-care products powered by hydroxyapatite. The company grew from the founders’ search for a clean alternative that would support enamel as well as remove unwanted ingredients, and its dentist-developed formulas are designed to be safe to swallow and backed by clinical science. RiseWell’s product line includes its signature and higher-concentration PRO mineral toothpastes for everyday family care and greater sensitivity needs.
Twice Twice LLCTwice Twice LLC was founded by a family of accomplished dentists, whose dental expertise still shapes the company’s approach to oral wellness. Based in Buena Park, California, it develops clean, science-backed care designed to connect everyday mouth health with overall well-being, while each purchase helps provide free dentistry to people in need.BUENA PARK, CA
OJOOK IncFounded by former Glossier and Apple executive Youn Chang after becoming a mother, OJOOK makes oral-care products that turn daily brushing into a mindful ritual. The company brings Eastern wellness philosophy and Korean bamboo salt together with dental research, most notably in its nano-hydroxyapatite toothpaste and compostable silk floss. OJOOK also emphasizes low-waste design, using recyclable aluminum toothpaste tubes and plastic-free floss packaging.New York, NY
Kaylaan LLCFounded by engineer Deepti Brambl and toxicologist Wells Brambl, Kaylaan makes toothpaste tablets and other plastic-free oral-care products at its FDA-compliant manufacturing plant in New York. The woman-owned, certified B Corporation developed its tablets during the pandemic as a cleaner alternative to conventional toothpaste tubes, packaging them in reusable tins with compostable refills. Kaylaan says its products have diverted more than 100,000 toothpaste tubes from landfills.FLORAL PARK, NY
Ortek-BasicBites®Founded in 1998, Ortek Therapeutics develops oral-health technologies and makes BasicBites, sugar-free soft chews designed to support enamel and the oral microbiome. The company’s work grew from a long-running collaboration with the Research Foundation for the State University of New York and Stony Brook University School of Dental Medicine, where its arginine bicarbonate and calcium carbonate technology was developed and clinically tested. Ortek also created the FDA-cleared Ortek-ECD device for early detection of occlusal cavities, while BasicBites brings its microbiome research into a daily consumer product manufactured in the United States at an FDA-registered, CGMP facility.ROSLYN HEIGHTS, NY