Twice Twice LLC was founded by a family of accomplished dentists, whose dental expertise still shapes the company’s approach to oral wellness. Based in Buena Park, California, it develops clean, science-backed care designed to connect everyday mouth health with overall well-being, while each purchase helps provide free dentistry to people in need.
RiseWellFounded in 2017 by John and Kori Estrada with Kori’s brother, dentist and prosthodontist Dr. Derek Gatta, RiseWell makes family-friendly oral-care products powered by hydroxyapatite. The company grew from the founders’ search for a clean alternative that would support enamel as well as remove unwanted ingredients, and its dentist-developed formulas are designed to be safe to swallow and backed by clinical science. RiseWell’s product line includes its signature and higher-concentration PRO mineral toothpastes for everyday family care and greater sensitivity needs.
Colgate-Palmolive CompanyColgate-Palmolive Company makes oral-care products for consumers and dental professionals, from everyday toothpaste and toothbrushes to prescription fluoride treatments and in-office whitening systems. Its Colgate Professional operation pairs those products with evidence-based education, patient resources, continuing education, and research support for the dental community. The company also sponsors initiatives such as the CARE research-grant program and awards for dental students and faculty.NEW YORK, NY
Ortek-BasicBites®Founded in 1998, Ortek Therapeutics develops oral-health technologies and makes BasicBites, sugar-free soft chews designed to support enamel and the oral microbiome. The company’s work grew from a long-running collaboration with the Research Foundation for the State University of New York and Stony Brook University School of Dental Medicine, where its arginine bicarbonate and calcium carbonate technology was developed and clinically tested. Ortek also created the FDA-cleared Ortek-ECD device for early detection of occlusal cavities, while BasicBites brings its microbiome research into a daily consumer product manufactured in the United States at an FDA-registered, CGMP facility.ROSLYN HEIGHTS, NY
Holmes DentalFounded in 1975 by practicing dentist Shelly Greene, DDS, Holmes Dental develops dental products that make procedures more comfortable for patients and more efficient for dentists. The Willow Grove company grew from Dr. Greene’s effort to solve product shortcomings in his own practice, including with its Sore Spotter for pinpointing denture trouble spots and its QYK-SET acrylic system. Holmes Dental now supplies dental products worldwide while continuing to develop solutions with dentists and buying groups.339114WILLOW GROVE, PA