Sam A. Lupo & Sons, Inc. is a family-owned Endicott food business known for Spiedies and the original Lupo’s marinade, first crafted at the family meat market. John and Sam A. Lupo opened that market in 1951; the business later expanded to family restaurants, a USDA meat plant, a bottling facility, and wholesale distribution. It remains run by Sam A. Lupo, Sr.’s sons Sam Jr. and Steve, with a third generation involved.