Founded by two doctors, Smileyscope develops medical-grade virtual-reality digital therapeutics that help clinicians reduce pain and anxiety during healthcare procedures. Its purpose-built headset and evidence-based software have supported more than 400,000 procedures across four continents, from children’s hospitals to rural clinics, and are designed to work without Wi-Fi or Bluetooth in everyday clinical settings. The company’s technology is FDA Class II cleared, TGA registered and CE marked.
FDA Class II Cleared
TGA Class 1 Registered
Registration
CE Marked
EN ISO 14971:2012
Compliance program
EN 62366:2008
Compliance program
EN ISO 10993-1
Compliance program
CE
Quality certification
MediView XR, IncCleveland-based MediView XR develops augmented-reality visualization and navigation systems that give clinicians a real-time, three-dimensional view of patient anatomy during image-guided procedures. Its platform fuses CT data with live ultrasound and supports remote collaboration, while its FDA-cleared XR90 has already been used clinically for minimally invasive navigation. The company grew from Cleveland Clinic-developed intellectual property and works with partners including GE HealthCare and Microsoft.CLEVELAND, OH
Vestibular FirstVestibular First began in 2017 when physical therapist Helena Esmonde and technology specialist Patrick Esmonde built a homemade prototype for a clinic that could not afford existing equipment. The Philadelphia company now makes modular infrared video goggles for vestibular clinicians, researchers, and educators, while keeping affordability and practical education at the center of its work.BROOMALL, PA
ARspectraFounded in 2018 after developing medical AR systems since 2013, ARspectra designs and manufactures purpose-built augmented-reality glasses and solutions for healthcare professionals and MedTech partners. Based in Luxembourg with a U.S. presence, the company develops medical-grade systems that put imaging, navigation data, and remote guidance directly in clinicians’ fields of view rather than adapting consumer AR hardware. ARspectra says it has produced more than 20 research, regulatory-ready, and commercial platforms for real-world surgical environments and operates as a certified MedTech manufacturer.NEW YORK, NY
VitaPixelBorn from retinal surgeon Christopher Riemann’s experience with a career-threatening neck injury, VitaPixel is developing a digital slit-lamp system that brings stereoscopic 3D viewing to XR glasses so ophthalmologists can examine patients upright. The Cincinnati-based team combines Riemann’s more than 25 years at the slit lamp with medical-device engineering and ophthalmic clinical experience. VitaPixel remains a pre-market startup; its device is not yet FDA-cleared or available for sale.