Founded by Luis M. Alvarez, whose work grew from questions raised by combat injuries, Frederick-based Theradaptive develops protein-engineering technologies for targeted tissue regeneration. Its platform creates material-binding protein variants that coat implants and carriers, including AMP2, an engineered BMP-2 variant now being evaluated in investigational spinal-fusion and dental bone-regeneration products. The company’s work spans vascular, soft-tissue, orthopedic and targeted therapeutic delivery applications.
ElutiaFounded by regenerative-medicine specialists C. Randal Mills and Michelle LeRoux Williams, Elutia develops biologic medical products that help implanted devices work more naturally with the body. Based in Gaithersburg, Maryland, the company builds on a proprietary drug-eluting biomaterial platform and engineered extracellular-matrix biology, with products for soft-tissue reconstruction and cardiovascular repair. Its SimpliDerm allograft and ProxiCor biomatrices are designed to support tissue integration and regeneration rather than simply provide inert structural support.GAITHERSBURG, MD
OrthofixFounded in 1980, Orthofix is a Lewisville, Texas-based medical technology company that develops devices and biologic solutions for spine care and limb reconstruction. Its work spans reconstructive and regenerative treatment, including bone-growth therapies and the 7D FLASH Navigation System, with products used to help patients regain mobility in more than 60 countries. Orthofix also develops biologics through its in-house tissue bank in Irvine, California, and collaborations with MTF Biologics.WAYNE, PA
Intelivation TechnologiesIntelivation Technologies presents itself as an innovation hub where surgeons and engineers develop biomedical technology for orthopedic and neurosurgical care. Based in Plymouth Meeting, Pennsylvania, the company designs and commercializes implants intended to support clinical results for patients while making procedures easier for surgeons.PLYMOUTH MEETING, PA
Auxano MedicalBorn from 1980s NASA ion-bombardment research at Case Western Reserve University, Brecksville-based Auxano Medical develops orthopedic implants designed to improve bone integration. Founded by biomaterials researcher Dr. George Picha, the company builds its products around a patented pillared surface morphology and applies it to procedures including midfoot fusion and flatfoot correction. Its research record includes 14 issued U.S. and international patents, two peer-reviewed publications, and a team with more than 75 years of combined orthopedic experience.BRECKSVILLE, OH