Founded in Bel Air, Maryland, WrinkleMD Skincare & Technologies Inc. makes at-home anti-aging infusion systems that use a Micro-Pulse Ion Activator Pod to deliver medical-grade hyaluronic acid through targeted patches. Developed with dermatologists and aesthetic experts after the team’s experience in aesthetic medicine, the company brings clinic-inspired delivery to a weekly home ritual, with clinical testing reporting up to 15-times deeper HA delivery and visible improvement within eight weeks.
FrowniesBorn from a mother-daughter invention in 1889, Frownies makes its signature facial patches along with complementary skincare designed to smooth and care for expression-prone skin. The woman-owned company remains in its fifth generation, and its Dayton, Ohio team handcrafts small batches of products such as its Bulgarian rose hydrosol spray. Frownies’ original patches use a water-activated adhesive that hardens to hold skin relaxed and flat, a distinctive approach the brand says predates injectable wrinkle treatments.DAYTON, OH
RescueMDPlastic surgeon-developed RescueMD makes skincare treatments designed to support the skin’s natural repair process, led by its DNA Repair Complex serum for scars, redness and post-procedure recovery. The company’s distinctive approach centers on lapachol, an exclusive ingredient described as targeting skin repair at the DNA level rather than only treating the surface. RescueMD products are developed, produced and manufactured in the United States, and the DNA Repair Complex carries the National Rosacea Society Seal of Approval.
Appolus LLCAppolus, a brand of Goldmine Natural Beauty, develops at-home beauty devices designed to bring dermatologist-style treatments into everyday routines. Founded by former Manhattan corporate professionals who used diamond microdermabrasion themselves, the company focuses on home-use microdermabrasion technology and checks products at approved factories through an independent inspection company.NEW YORK, NY
DR. MACRENE activesFounded around the work of dermatologist-scientist Macrene Alexiades, MD, PhD, DR. MACRENE actives makes dermatologist-developed skincare designed to bring clinical research into everyday formulas. The New York company’s products are built around its patented MA37™ multi-active technology and plant-derived ingredients, while its Manhattan and Wainscott spas extend that approach into personalized treatments. Alexiades holds BA, MD, and PhD degrees from Harvard and is dual board-certified in dermatology in the United States and European Union.NEW YORK, NY