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Founded by pharmacists in 2013, Acnos Pharma supplies and manages medicines for clinical trials from preclinical work through Phase I–III studies. The Germany-based company combines direct and local sourcing with clinical packaging, temperature-controlled warehousing and cross-border logistics, supported by a 1,700-square-metre facility and partners in more than 50 countries. Its U.S. operation, Acnos Pharma CTS LLC, is women-owned and led and WBENC-certified, while the wider business holds GDP and GMP credentials and operates under EU and German wholesale distribution authorisations.
Since Sarkis Acopian founded the company in 1957, Acopian Technical Company has manufactured AC-DC and DC-DC power supplies in the United States, including systems used in aerospace and even outer space. Based in Easton, Pennsylvania, the company has sold more than 7 million power supplies and continues to build standard and custom units, with many models shipped within three days. Acopian is ISO 9001 certified and backs its metal-enclosed power supplies with a five-year warranty.
Founded in 1972 as a Cleveland patient-care facility, Acor Orthopedic now manufactures, converts and distributes foam interface materials while making custom ankle-foot orthotics under its AXIS line. The company combines pedorthic expertise with engineers, artisan craftsmen and manufacturing specialists, and its AXIS AFO devices are made in the USA for customers worldwide.
Since 1957, Acorn Industrial Products Co. has supplied and manufactured industrial motion and maintenance equipment, with a particular focus on casters and wheels. Its King of Prussia operation makes standard and custom Nylacron™ cast-polyamide wheels in-house on CNC equipment, producing wheels up to 51 inches in diameter and fitting them with precision bearings for demanding applications. Acorn also provides application assistance, in-plant caster and wheel surveys, machinery installation accessories, count-control systems and portable metalworking tools.
Founded in 1978 in upstate New York, Acorn Products Corporation grew from two injection molding machines in an old gas station into an Ilion manufacturer of custom injection-molded plastics. Today, the company operates 16 injection molding machines and supports projects from prototype through production, with production records and first- and last-part inspections used to track quality. Michael P. Quinn has owned the business since 2013.
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Founded by pharmacist Shawn Nairn in 2016, Carnegie-based ACORx Pharmacy organizes complex medication regimens into dated, pharmacist-reviewed adherence packages and delivers them to patients’ homes. Its concierge model connects pharmacists with patients, caregivers, and providers between visits, with a particular focus on making medication management safer and easier for people taking multiple prescriptions. ACORx has been recognized among Pittsburgh’s fastest-growing companies, including the Pittsburgh Business Times Fast 50 in 2020 and 2025.
Founded by Mexican-American Frank Acosta as a tribute to his heritage, Acosta Tequila makes small-batch, ultra-premium tequila from 100% Blue Weber agave in Jalisco, Mexico. Its traditional approach includes slow-baking agave in stone ovens and aging the tequila in Cognac barrels, while a patented bottle and cap draw on Mesoamerican architectural heritage. The distillery is a third-generation family farm certified by Industria Limpia, and the brand supports jaguar preservation through a portion of every sale.
From a kitchen-table invention by Erie husband-and-wife founders Wei-Shin Lai, MD, and Jason Wolfe, AcousticSheep makes comfortable headphones built into headbands for sleeping and exercise. Founded in 2007, the company manufactures and sells its SleepPhones and RunPhones brands from Erie, where Lai and Wolfe still own and run the business with a 30-person team serving customers around the world. Its patented designs have earned multiple Consumer Electronics Show Innovation Awards, including for SleepPhones Wireless and RunPhones Wireless.
From a used single-wide trailer in 1986 to a 72,000-square-foot Arlington plant, ACP International makes the utility identification products and custom signs that keep underground infrastructure visible and understandable. The American manufacturer is 100% employee-owned through an Employee Ownership Trust—the first of its kind in Texas—and produces its products in-house for utilities, contractors, municipalities, and other infrastructure users. Its family of brands extends that work into traffic safety, streetscapes, pavement graphics, and industrial safety.
Founded more than 28 years ago by technology entrepreneur Steve Seiden, Acquired Data Solutions is a Rockville small business known for helping government and commercial organizations address difficult engineering challenges. It grew from a test-and-measurement firm into a provider of secure technology solutions, with a particular focus on mission-critical work and long-term government relationships. ADS holds ISO 9001:2015 certification.
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Acreage Holdings is a cannabis company founded in 2011 that cultivates, produces and dispenses cannabis products and brand experiences. It describes a vertically integrated model spanning cultivation, processing and manufacturing, and dispensing, alongside distinct consumer brands serving modern consumers and patients.
Privately owned since its founding in 1974, Acro Industries is a Rochester, New York manufacturer known for keeping projects—from early prototypes through full production—under one roof. Its four climate-controlled facilities span more than 150,000 square feet and employ over 150 people, supporting customers in demanding sectors such as aerospace and transportation. Acro’s quality system is ISO 9001:2015 registered, and the company is also ITAR registered.
Founded in 1972, Acro Labels Inc. is a Willow Grove label manufacturer that grew from a single press in a Philadelphia-area basement into a company employing close to 40 people and operating 14 presses. It produces custom pressure-sensitive labels, combining traditional flexographic printing with digital printing and laser die cutting. Its in-house capabilities serve customers across a range of industries, and the company also works with print and graphic arts brokers.
RoHS-compliant since 1983, Acro-Fab is a Hannibal manufacturer known for precision sheet-metal fabrication serving both production and prototype needs. Its in-house chemical-film line supports aluminum finishing and helps keep work on a shorter lead time.
Founded in 1994, Acrolite, Inc. is an OEM contract manufacturer of glass-fiber-optic lighting and sensing assemblies for medical and industrial applications. Its Elbridge operation draws glass fiber and develops custom fiber-optic components, including its Acrofusion cable termination process.
AcromaPro carries the legacy of Beckers, the Swedish paint and varnish company founded in 1874, into modern industrial wood finishing. Renamed from Becker Acroma in North America in 2014, it develops coatings for manufacturers whose furniture and millwork need durable, consistent finishes, including waterborne and UV-curing solutions.
Acromet Metal Fabricators is the trade name of GT Metal Fabricators Inc., a Strongsville, Ohio metal-fabrication shop. It provides engineering and custom sheet-metal fabrication, supporting customers with work such as laser cutting and CNC machining.