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Born in 1936 in Elmer VanSickle’s basement factory, Cleveland Wheel & Brake Systems has carried its aircraft-braking heritage from general aviation into military and rotorcraft programs. The Signia Aerospace company still manufactures its wheel and brake assemblies in the USA at its Avon, Ohio, factory while supporting aircraft operators through a global distributor network.
Founded by A.L. Crone in Cleveland in 1914, Cleveland Wirecloth & Manufacturing Co. weaves industrial wire cloth and turns it into precision-fabricated components for demanding applications. The company designs and manufactures in-house, combining more than a century of weaving expertise with engineering support and capabilities such as laser cutting. A founding member of the American Wire Cloth Institute, Cleveland Wirecloth maintains ISO 9001:2015 and AS 9100D certifications and remains family-owned following its 2023 acquisition by Freshwater Capital.
Founded in 1847, Cleveland-Cliffs is a North America-based, vertically integrated steel producer with operations across the United States and Canada. It mines iron ore and makes steel, then carries out downstream finishing, stamping, tooling, and tubing; its products include value-added sheet steel supplied particularly to the automotive industry. The company reports 60 operating facilities and approximately 25,000 employees as of February 2026.
Clever Leaves is a multinational licensed producer of pharmaceutical-grade cannabis flower, cannabinoids and extracts, operating cultivation and extraction facilities in Colombia for business customers worldwide. Its Pesca cultivation site has grown from one hectare to 18 and uses high-altitude sunlight and collected rainwater, while the company’s vertically integrated supply chain supports exports to roughly 15 countries. Clever Leaves was the first company in Colombia to achieve both GACP and EU GMP certification, in 2020.
Since 1968, New York–based Cliff Young Ltd. has designed and curated fine home furnishings, with a Signature Collection of customizable pieces shaped by the founder’s background in furniture and the arts. The family-held and family-led company combines in-house design consultation with traditional craftsmanship and modern manufacturing, producing heirloom-quality work while also offering distinctive designs from global artisans. Its hand-knotted-in-Nepal rugs and bespoke furniture capabilities remain especially characteristic of the Cliff Young approach.
Known for its deep Quadrajet expertise, Cliff’s High Performance helps vintage-GM enthusiasts bring original carburetors back to dependable street and track service. The Mount Vernon, Ohio, shop builds application-specific rebuild kits and tunes carburetors around each customer’s vehicle rather than treating every unit as an off-the-shelf job.
Founded in 2013, Clifford CNC Tooling Surgeon, LLC is a rapid-response EDM tool room in Adams County, Pennsylvania, making ultra-precision machined parts and custom tooling for government agencies and small and mid-sized businesses. Neil Clifford works directly with clients on tool design, precision machining, and difficult EDM work, including small deep holes and wire-cut features for prototype and production projects. The company serves customers across the Mid-Atlantic and Northeast and is proudly made in the USA.
Locally owned since 1991, Clifton Recycling Inc. is a Central New York business best known for turning wood waste into mulch. Its work has expanded to include organic wood grinding and material hauling for customers ranging from homeowners to municipalities, with operations in Syracuse and Clay.
Since opening in 1971, Clifton Steel has built its identity around solving difficult wear problems for industrial customers from its Maple Heights operation. Its 140,000-square-foot facility reflects that practical, in-house approach, with the company producing custom components and military armor plate while supporting customers in fields such as recycling and mining. Clifton Steel holds ISO 9001:2015 and CMMC Level II certifications.
Founded in 2001, Climatic Testing Systems, Inc. is a Hatfield, Pennsylvania technology company known for applying deep refrigeration and controls expertise to custom test facilities. Its team brings more than 100 years of combined experience to environmental testing projects for automotive, HVAC and pharmaceutical customers, providing support from design through commissioning and maintenance.
From its Mentor, Ohio operation, Climax Metal Products Company makes engineered shaft-locking and motion-control components, with shaft collars and rigid couplings at the core of its catalog. The company also supplies keyless locking devices under an exclusive agreement with MAV S.p.A. of Italy, alongside Clesco mounted bearings and abrasive hardware. Climax Metal Products Company holds ISO 9001:2015 certification.
For more than a century, Cincinnati-based Climax Packaging Machinery has made packaging equipment, dating its work to 1916. The company is especially known for producing more than 1,200 EUI uncasing machines and serves beverage makers along with manufacturers in several other industries.
Climbing Bines Craft Ale Company grew from an eight-plant home-brewing experiment into a Finger Lakes farm brewery making small-batch ales with hops grown on its own 1.5-acre hop yard. Founded by Chris Hansen and Matt Klehammer, the brewery opened in 2013 in Chris Hansen’s grandfather’s renovated farm shed and now pairs fresh-off-the-farm beer with views of Seneca Lake and a community taproom. Its 16-acre property also serves as an event venue, including a 4,000-square-foot indoor space.
For more than three decades, Clinical Intelli-Print has been the specialist print partner behind clinical research studies, serving sponsors, CROs and agencies. The company handles trial materials and their fulfillment, with processes built around the accuracy and deadlines required in a tightly regulated field.
Clinical Prosthetics & Orthotics grew from offices established by David Misener and Dennis Ebbing in 2001 into a five-location Upstate New York practice. Its American Board Certified providers bring more than 30 years of experience to personalized care for people with limb loss, limb difference, or conditions affecting mobility.
CLINICAL SUPPORT CENTER INC operates in the Personal Care Product Manufacturing industry.
Clinigen Group helps pharmaceutical and biotechnology companies move medicines through clinical development and into patients, combining clinical-trial supply management with managed access and global partnering. With regional teams across North America, Europe, Africa, Japan and Asia Pacific, the company has accelerated access to medicines in more than 130 countries. Clinigen also supplies hard-to-find and unlicensed medicines through its Clinigen Direct platform, drawing on more than 30 years of experience in that work.
Clinimed USA is a fourth-generation, family-owned manufacturer of surgical instruments and medical devices, founded in 1978 and shaped by a family metalsmithing tradition that reaches back to 1916. The company serves as a turnkey OEM partner, combining custom design and development with vertically integrated production and distributing more than 16,000 instruments and devices across 22 surgical specialties. Its facilities are FDA registered and cGMP and ISO 9002:13485 compliant.
Clinton Controls, Inc. is a central Pennsylvania company with 30 years of experience building custom electrical control panels. Its systems serve pumping and water treatment operations, with thousands in use across the United States and abroad; the company also provides field troubleshooting for industrial controls regardless of manufacturer.
Founded in 1979 by Robert C. Bohn, Clinton Industries makes medical and physical therapy furnishings and equipment. It grew from a garage startup focused on more affordable treatment tables into a company operating more than 300,000 square feet of combined manufacturing and warehouse space, with national and international distribution.