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MD
Olde Mother Brewing Co. is a Frederick, Maryland craft brewery founded by longtime friends Nick and Keith, who set out to brew good beer while building a community around it. Its taproom balances traditional brewing with experimental releases, including collaborations such as the Japanese rice lager Send Noods, and hosts local gatherings from trivia nights to live music.
Since 1993, Oliver Brewing Co. has brewed distinctive American ales in Baltimore, drawing on traditional brewing methods while exploring new styles, ingredients, and flavors. As one of Baltimore’s original craft brewers, the company pairs a long local history with an evolving lineup of beers.
Known for putting plant-based omega-3 nutrition into convenient brain-health snacks, Omega 3 Nutrition makes granola bars and cereal bites in the United States. Its school-focused products are tree-nut-free and are used by nearly 1,000 schools nationwide, with formats designed for cafeteria service and USDA meal-pattern requirements.
Born from a makeup artist’s frustration with shades that overlooked deeper complexions, Omolewa Cosmetics makes high-performance makeup for women of color, including a 31-shade foundation range. Its U.S.-made formulas were tested in Ghana’s heat and humidity and are built for lightweight, smudge-proof wear that lasts through real life. The brand also extends its mission through makeup education, women’s events, and its Without Fail storytelling project.
Co-founded by Dr. Geoffrey Ling after experiences in Afghanistan and Iraq, Rockville-based On Demand Pharmaceuticals develops distributed systems for producing medicines at or near the point of care. Its Pharmacy on Demand™ platform supports agile 503A and 503B production, including sterile injectables, to help hospitals respond to drug shortages and reduce dependence on fragile global supply chains. A 2024 pilot with North Mississippi Health Services produced approximately 12,000 prefilled syringes without a quality failure or adverse patient event.
Founded by entrepreneur Eric Brock, Ondas Inc. is a technology company known for bringing autonomous systems into demanding defense and critical-infrastructure work. Its businesses provide AI-enabled drones and private wireless connectivity to government and industrial customers, including the FAA-approved Optimus system for automated aerial operations.
Founded by Michael Shane on March 15, 1995, OnSight Optical is a Clearwater company built around bringing optical dispensing into ophthalmology practices. It supports partner practices with an in-practice optical operation and serves settings ranging from private offices to hospitals and surgery centers. The company says its support team has 100 years of combined experience in the optical field.
Founded in 2015 by pharmacist and mother of three Nina Farzin, oogiebear makes doctor-designed baby-care tools that help parents clear little noses and ears more gently. The company is best known for its patented, bear-shaped dual-ended booger picker, which grew from Farzin’s experience caring for her own congested babies and later appeared on Shark Tank, where oogiebear secured an investment deal. Its collection has expanded into everyday newborn-care essentials, including oral-care tools and organic balms.
Founded by cardiac anesthesiologist and airway expert Dr. James Gayes, OPAD Airway develops the Optimum Patient Adjustment Device, an inflatable patient-positioning device designed to promote first-pass intubation. The company grew from Dr. Gayes’s experience managing thousands of complex airways and focuses on making intubation safer and more consistent, particularly for obese patients, across hospital and non-operating-room anesthesia settings.
Founded in 2016 to rebuild Baltimore’s manufacturing economy from the grassroots up, Open Works is a nonprofit makerspace where members use shared fabrication shops, studios and classes to turn ideas into products. Its 34,000-square-foot facility also provides contract fabrication, producing projects such as Baltimore’s solar-powered Wi-Fi stations and custom furniture. The organization supports about 118 jobs, works with more than 1,000 young people each year and runs an annual competition that has invested in Maryland manufacturing startups.
Trauma surgeon Dr. Robert Buckman founded Operative Experience to bring hands-on surgical realism to healthcare training, and healthcare simulation pioneer Lou Oberndorf joined the company in 2016 to accelerate its development. Based in Maryland, the company designs and manufactures high-fidelity human simulators for military and civilian medical education, including its U.S. Army-accredited female PCCS Pro trauma simulator.
Since 1979, Lowell-based Optec, Inc. has designed and manufactured electro-optical equipment that helps astronomers and astrophotographers capture better images. The small firm also develops solutions for atmospheric science and microscopy, pairing specialized products with software support for astronomy users around the world.
Founded in 1985, Optical Scientific, Inc. develops and manufactures optical scintillation-based sensors, environmental monitoring solutions, automated weather stations, optical flow sensors, and precision optical instruments. Its systems measure precipitation, present weather, visibility, air and gas flow, crosswinds, and atmospheric turbulence for airports, highways, railroads, maritime operations, power plants, refineries, environmental monitoring, and other industrial and research applications.
OptimaBiome is a decarbonization company developing technology for transportation emissions. Its mobile carbon-capture approach uses a reusable solid matrix to capture CO2 from vehicle exhaust and move it toward storage, offering a bridge as transportation shifts toward net-zero operation.
Optimum Labs LLC manufactures upper-extremity prosthetic devices, custom rolled silicone liners, and fabrication tools for the clinicians who build them. Its work combines custom CAD and 3D-printed cores with silicone fabrication, while its small equipment line includes practical solutions such as the BubbleUP plaster degassing tool and adjustable prosthetic components. The company also offers digital fabrication files and says custom fabrication typically takes two to three weeks.
Founded in 2019, Optosurgical is a Columbia, Maryland startup developing surgical-vision technology for clinicians working in minimally invasive procedures. Its research centers on making critical anatomy visible in real time, including through the hANDY-i system for parathyroid visualization. The company’s work has received NIH and ARPA-H SBIR Phase II support and is being developed with clinical partners including Johns Hopkins Hospital.
Orano’s Kevil, Kentucky facility is known for specialized freight forwarding for the nuclear industry, moving radioactive cargo for customers across the front and back ends of the fuel cycle. The site also operates a cylinder service center and supports licensed packaging work under an NRC-approved NQA-1 quality program.
Established in 1984, Orca, Inc. is a Connecticut manufacturer known for more than 35 years of specialized work in rigid metal packaging. Its Unitop utility cans serve industrial and chemical applications, with order quantities ranging from a single carton to multi-truckload and rail shipments.
Woman-owned and family-operated in Middletown, Maryland, Orchid Cellar Meadery and Winery crafts mead and wine, bringing the world’s oldest alcoholic drink into a modern setting. Its locally made beverages have earned international awards while building a distinctive Maryland identity.
Founded in 1996, Rockville-based OriGene Technologies develops genomic and proteomic research tools, anchored by a proprietary collection of more than 586,000 full-length human cDNA clones. Its catalog now exceeds one million products, while custom work runs from gene cloning through protein purification and includes antibody specificity testing using high-density protein microarrays. OriGene also manufactures custom proteins in the United States and serves researchers worldwide.