Founded in 2016, Baltimore-based Longeviti Neuro Solutions develops cranial implants and neurotechnology platforms for complex brain surgery. Its ClearFit® platform combines skull reconstruction with a Brain Ultrasound Interface, allowing clinicians to image the brain through the implant after surgery, while its low-profile implants are designed to restore the skull’s natural contour and accommodate neurosurgical devices. The company reports 20 U.S. patents, 36 worldwide patents, and several FDA-cleared implants brought to market since 2018.
FDA-cleared implants
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Actuated Medical, IncFounded in 2006, Bellefonte-based Actuated Medical develops medical devices that improve precision access to deep brain targets, led by its NeuralGlider® platform for brain-directed therapy delivery. The company’s motion-based technology has been developed and validated over more than a decade, supporting research groups worldwide as Actuated advances applications in neurosurgery and neurotechnology. Actuated Medical operates a 20,000-square-foot facility and is ISO 13485 certified, FDA registered, and recognized as a Woman Owned Small Business.BELLEFONTE, PA
ReVivo MedicalReVivo Medical develops spinal-surgery implants, with its CEM-Plate and CEM-Cage currently under investigation in an FDA-sanctioned first-in-human clinical trial. Based in Loudonville, the company was founded by spine surgeons and biomedical researchers to improve patient outcomes while simplifying operating-room workflow and reducing implant components. Its work is backed by 18 issued U.S., European, and Canadian patents, as listed by the company.LOUDONVILLE, NY
Intelivation TechnologiesIntelivation Technologies presents itself as an innovation hub where surgeons and engineers develop biomedical technology for orthopedic and neurosurgical care. Based in Plymouth Meeting, Pennsylvania, the company designs and commercializes implants intended to support clinical results for patients while making procedures easier for surgeons.PLYMOUTH MEETING, PA
Cranial TechnologiesFounded in 1986, Cranial Technologies develops and provides infant head- and ear-shape correction, including its custom DOC Band® cranial orthotic and EarWell® newborn ear-molding system. The company says it is the sole provider of the DOC Band, the first FDA-cleared cranial orthotic for plagiocephaly, and has treated more than 500,000 babies through a network of over 100 clinics. Its pediatric-focused teams use 3D imaging, custom fitting, and ongoing follow-up to guide families from evaluation through treatment graduation.HUMMELSTOWN, PA