Founded in 1983 by Martin Bak, Gaithersburg-based Microprobes for Life Science designs and fabricates implantable neural microelectrodes, multichannel arrays, and related systems for electrophysiology research. With more than 30 years of microelectrode expertise, the company is known for tailoring neural interfaces to specialized research applications, including its chronic Floating Microelectrode Array and wireless successor. Microprobes serves research institutions and pharmaceutical and medical-device companies worldwide and is ISO 9001:2015 certified.
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Diagnostic BiochipsFounded in Glen Burnie in 2013, Diagnostic Biochips develops neural probes and recording systems that let researchers measure brain activity inside intact organoids and other neural models. Its SomaFocus platform combines high-density silicon probes with automated depth recording, real-time analysis, and cloud-based data storage, extending electrophysiology beyond surface-level measurements. The company grew from technology developed at the University of Michigan and through Howard Hughes Medical Institute’s Janelia Research Campus, with more than $6 million in NIH and DARPA research funding.GLEN BURNIE, MD
Enzo Life Sciences, IncEstablished in 1976, Enzo Life Sciences develops and manufactures labeling and detection technologies that support life-science research, drug discovery, biopharmaceutical development, and diagnostics. From its Long Island headquarters campus, the company combines in-house U.S. manufacturing with more than 45 years of experience and has produced over 20,000 life-science products. Enzo also provides custom and GMP manufacturing through facilities certified to ISO 9001 and ISO 13485.FARMINGDALE, NY
Threshold NeuroDiagnosticsThreshold NeuroDiagnostics makes the Medusa Electrode, an FDA-registered Class II device that adapts neuromodulation leads to universal EEG connectors so clinicians and researchers can record neural signals with standard neurophysiology equipment. Founded around the hands-on expertise of Geoffrey Allott, the company draws on more than 16 years connecting to neuromodulation electrodes and experience with over 400 human-subject procedures. Its work also supports research into brain and spinal stimulation, including biomarker access and neural-network mapping.
Applied BioPhysics, IncFounded in 1991 by the inventors of Electric Cell-substrate Impedance Sensing, Applied BioPhysics manufactures ECIS® instruments and electrode arrays that monitor living cells in tissue culture in real time. Based in Troy, New York, the company applies biophysical research to cell research and drug discovery, with 95 percent of its products made at its U.S. facility. Its systems give researchers a label-free way to study cell behavior while maintaining active connections with the academic community that helped shape the technology.TROY, NY