Founded in May 2026 by Sean Lin in Carrollton, National Cold Vault is building cellular temperature monitors for medical refrigerators holding privately purchased vaccines and other temperature-sensitive medicines. Its LTE-M units use an independent battery-backed connection instead of facility Wi-Fi, while tamper-evident records and annual probe replacement are designed to support inspections and document excursions. The new Ohio company plans to ship its first 50 units by March 31, 2027, with Lin handling customer support and local delivery himself.
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CSafeFounded in Ohio in 1979, CSafe makes temperature-controlled shipping systems that protect life-science products from the manufacturer to the patient. Its active and passive cold-chain packaging is paired with qualification services and CSafe Connect real-time shipment visibility, supporting deliveries across more than 185 countries. The company says its products have safely carried more than 10 billion doses.MONROE, OH
So-Low Environmental Equipment CoFrom a Cincinnati home garage in 1959, So-Low Environmental Equipment Co. has grown into an American manufacturer of ultra-low-temperature freezers and medical-grade laboratory refrigeration equipment. Its Cincinnati factory serves research, medical and industrial organizations with U.S.-made cold-storage systems, including specialized units for flammable materials and hazardous locations. So-Low also emphasizes personal support, with live customer service and in-house parts and service assistance throughout a freezer’s life cycle.CINCINNATI, OH
Cryothermic SystemsFounded in 2008 in Cleveland, Ohio, Cryothermic Systems develops medical devices that cool the body rapidly and noninvasively, led by its Cryo Cooling System for targeted temperature management. Its activated cooling packs reach -5°C in seconds and are designed to start cooling in the field before patients reach emergency, cardiac, or intensive care. The company was founded by Harvard-trained cardiothoracic surgeon Aqeel Sandhu and was formerly known as Life Core Technologies.CLEVELAND, OH
Refrigerated Transport Electronics, Inc. (RTE)Founded in 1981, family-owned and operated Refrigerated Transport Electronics (RTE) develops and manufactures technology for refrigerated transport and the cold chain. The McGraw, New York company is known for pioneering reefer monitoring and electronic reefer-controller remanufacturing, and its products serve operations from marine terminals to product-level shipments.MCGRAW, NY