PeriphaGen is a Pittsburgh biopharmaceutical company developing replication-defective HSV-1 gene-therapy vectors, with a particular focus on delivering treatments to peripheral nerves and difficult-to-treat neurological disorders. The company has worked with HSV-1 vectors for more than 25 years and was the first to conduct human clinical trials using replication-defective HSV-1 vectors. Its NET platform uses the virus’s natural transport along sensory neurons to deliver high-capacity genetic payloads, while PeriphaGen also provides vector design and production technologies for research and clinical development.
Krystal Biotech, IncPittsburgh-based Krystal Biotech develops and commercializes redosable genetic medicines for rare diseases, using an engineered HSV-1 vector platform designed for focal, minimally invasive gene delivery. Its first commercial product, VYJUVEK®, is the first and only redosable gene therapy for dystrophic epidermolysis bullosa, while two U.S. GMP facilities—including a roughly 155,000-square-foot ASTRA site—support manufacturing and pipeline development. Krystal is fully integrated across vector design, gene therapy manufacturing and commercialization.325412PITTSBURGH, PA
Patheon pharma services (Thermo Fisher Scientific)Patheon Pharma Services is the pharmaceutical services business of Thermo Fisher Scientific, known for more than two decades of viral-vector development and manufacturing experience. It helps biotech and pharmaceutical developers move medicines from early development through clinical trials and commercial production, with specialized work in mRNA and gene-therapy programs.ALLENTOWN, PA
Renerva, IncFounded in 2017 out of the University of Pittsburgh and Cornell University, Pittsburgh-based Renerva develops implantable medical devices and biomaterials for peripheral nerve injury, including its investigational PNM-CAP nerve-capping device for neuroma pain. The company’s research centers on decellularized porcine nerve extracellular matrix, with products intended to help limit painful nerve growth or support nerve recovery; its technologies are not yet commercially available. Renerva operates from Pittsburgh with a satellite location in Ithaca, New York.PITTSBURGH, PA
Vector BioMedSpun out of the nonprofit Caring Cross, Vector BioMed develops and manufactures lentiviral vectors for gene and cell therapy programs. Its LENTIVERSE™ platform combines custom vector engineering with ready-to-deploy solutions for CAR-T manufacturing, using a platform-based approach intended to shorten the path from concept to clinic. The Gaithersburg public benefit corporation pairs decades of lentiviral experience with a focus on transparent economics and expanding access to advanced therapies worldwide.GAITHERSBURG, MD