Philadelphia-area medical device company RTM Vital Signs develops wearable and implantable systems that continuously monitor respiratory and cardiac health in real time. Its AI-driven RTMsense respiratory system received FDA 510(k) clearance in 2025, while the company’s cardiac monitoring technology is supported by 13 issued patents. Founded by executives Nance Dicciani and Denise Devine alongside anesthesiologist and medical-device inventor Dr. Jeff Joseph, RTM also received first prize for innovation at the 2023 American Society of Anesthesiology Conference.
FDA 510(k) Clearance for RMS GEN I
FDA Breakthrough Device Designation
Compliance program
Health Care Originals, IncBorn from co-founder Sharon Samjitsingh’s experience with severe asthma, Rochester-based Health Care Originals develops cardiopulmonary wearable systems and the software that turns respiratory data into usable insight. Its ADAMM platform supports asthma and COPD care, telemedicine, and clinical research by tracking symptoms such as cough and breathing patterns between visits as well as during remote consultations. The company’s technology has received recognition including CES 2015 honors and Innovation World Cup awards.ROCHESTER, NY
CircadianceFounded in 2006 near Pittsburgh by medical-device engineer David Groll, Circadiance develops and manufactures respiratory-care equipment and remote patient-monitoring systems. The company is best known for SleepWeaver, the first all-cloth positive-airway-pressure mask, and also supports infant and pediatric care through SmartMonitor and Synergy Cloud products. Circadiance is ISO 13485 certified and distributes its products internationally.EXPORT, PA
LASARRUSFounded by four brothers with more than 50 years of combined professional experience, LASARRUS develops WearME, an AI-powered wearable and software system for continuous COPD monitoring and early detection. The company’s research-driven platform tracks physiological signals and gives clinicians actionable insight into changes in a patient’s condition. LASARRUS has won Intel’s 2018 design contest, received three SBIR grants, and been awarded four patents as it works toward FDA clearance.BALTIMORE, MD
PinMed IncPinMed develops high-fidelity cardiovascular monitoring systems and personalized software for clinicians, researchers, and health consumers working in demanding environments. Its flagship PELEX platform is a pocket-size, FDA-cleared diagnostic 12-lead ECG system that also supports ambulatory monitoring and wireless data transmission. The company also provides integrated research systems and custom solutions, including monitoring designed for MRI- and X-ray-guided procedures, and has been recognized with a National Innovation Award.PITTSBURGH, PA