Founded in 2010 by a longtime aortic-valve researcher, Thubrikar Aortic Valve develops transcatheter aortic valve systems for treating aortic stenosis. Its investigational Optimum TAVI System is based on more than 30 years of research into the geometry and mechanics of the natural valve, with durability as a central design goal. The privately held, clinical-stage company has partnered with Brazil’s Labcor Laboratórios and is conducting studies in Europe.
Transonic Systems IncFounded in 1983 by Cornell engineer Cornelis Drost, Transonic Systems develops biomedical flow-measurement tools built around the transit-time ultrasound technology he pioneered. From its Ithaca headquarters, the company supports clinicians, researchers and medical-device developers with quantitative measurements used from operating rooms and dialysis clinics to life-science laboratories and OEM devices. Transonic’s 120-person organization manufactures in an ISO 13485:2016-certified facility and has supplied flow technology cited in thousands of studies.ITHACA, NY
ThrombolexBuilt around physician Riyaz Bashir’s BASHIR™ platform, Thrombolex makes endovascular catheters that combine mechanical clot fragmentation with targeted thrombolytic delivery for arterial and venous thromboembolic conditions. The New Britain, Pennsylvania medical-device manufacturer markets multiple FDA-cleared devices, including catheters with expandable infusion baskets designed to restore blood flow in peripheral and pulmonary vessels. Its leadership and clinical programs draw on more than 100 years of combined experience and partnerships across the medical field.NEW BRITAIN, PA
Minivalve International B.VFamily-owned Minivalve International B.V. began about 25 years ago with a single-minded focus on miniature valve components and has grown from three colleagues into a 110-person manufacturer in Oldenzaal. The company develops and produces fluid-control components for OEMs, keeping its work under one roof and supplying customers in fields such as medical devices and automotive equipment. Its quality system is certified to ISO 9001, IATF 16949, and ISO 13485.CLEVELAND, OH
Neoolife, IncPittsburgh-based Neoolife, Inc. is a pre-clinical Bio-MedTech startup developing tissue-engineered biomimetic heart valves and cardiovascular patches designed to support the body’s own tissue regeneration. Its distinctive Double Component Deposition technology creates non-animal-derived polymeric scaffolds, including the OneValveTric transcatheter tricuspid valve system, while the company’s international team brings more than 130 years of combined biomedical and cardiovascular experience. The technology has received support through NIH and European Research Council grants, but Neoolife’s products remain in research and pre-clinical development and are not yet approved by regulators.PITTSBURGH, PA