San Francisco-based VENTSAFE develops mechanical ventilation devices for intensive care units, with a focus on improving respiratory support for patients in critical condition. Its ongoing development work incorporates adaptive technology, artificial intelligence and clinician feedback as the company advances its ventilation platform.
Respair, IncBorn from University of Pittsburgh clinical research, Pittsburgh-based Respair develops airway devices for ventilated patients, beginning with RelianceET, a breathing tube designed to replace the conventional inflatable cuff with soft baffles that seal the airway without added pressure. Founded by physicians Carl Snyderman and Garrett Coyan, the company brings surgeons, engineers, and entrepreneurs together to address ventilator-associated complications. Respair completed hundreds of benchtop tests and received a Phase I SBIR award from the NIH while advancing the device toward regulatory submission.PITTSBURGH, PA
VapothermFor more than 25 years, Vapotherm has made respiratory-support devices built around high velocity therapy, its mask-free approach for spontaneously breathing patients from premature neonates to adults. Based in Exeter, New Hampshire, the medical-device company’s portfolio includes the HVT 2.0 and Precision Flow systems, alongside a portable ventilator developed with Flight Medical. Vapotherm products are used in more than 2,400 hospitals across over 40 countries.CINCINNATI, OH
Lungpacer Medical IncFor more than 15 years, Lungpacer Medical has developed neurostimulation technologies for critical care, including the AeroPace temporary transvenous system that activates the diaphragm to help mechanically ventilated patients regain independent breathing. The company’s work spans clinical research and engineering, with its first human diaphragm-pacing use in 2015 and FDA premarket approval for AeroPace in 2024. Based in Vancouver with U.S. operations in Exton, Pennsylvania, Lungpacer is also studying continual diaphragm stimulation through its investigational AeroNova system.EXTON, PA
Spiritus Medical, IncSpiritus Medical, Inc. makes and distributes the VITALITY ventilator, a NASA JPL-designed pneumatic ICU ventilator. The company presents the ventilator as made in the USA and intended for global healthcare and respiratory-support needs.COLUMBUS, OH