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On 31 acres along 18 Mile Creek in Newfane, husband-and-wife winemakers Jim and Kathy Baker grow their own grapes and make predominantly dry wines shaped by the Niagara Lake Plain. Founded in 2006, Chateau Niagara Winery is family-owned and known for pairing classic French varieties with less-common Eastern European grapes such as Saperavi. The Bakers host intimate, hands-on tastings themselves, and the vineyard is among New York’s first certified sustainable vineyards.
Founded in 1948 as a brick-and-block manufacturer, family-run Chautauqua Brick has grown into a Southern Tier building-materials supplier with four locations. Now in its third generation, the company still makes masonry products while supplying materials for projects from foundation to rooftop, backed by outside sales, project estimates and specialized delivery. Its long history and family leadership remain central to the way it serves homeowners, contractors and architects.
Founded in 1951, Chautauqua Chemicals Co., Inc. develops and manufactures industrial cleaning, degreasing, and rust-preventative chemicals for manufacturing processes at its Ashville, New York facility. Through its Miraclean and Chautauqua Metal Finishing Supply divisions, the company also serves metal-finishing customers as a distributor of related equipment and supplies. Its technical staff supports customers ranging from small job shops to Fortune 500 companies, with in-house testing and custom formulation available for specific process needs.
Founded in 2009 by former New York State Conservation Police Chief Bob and his wife Michelle, Chautauqua Hydroseeding LLC restores and establishes lawns while handling the grading and erosion-control work around them. The Bemus Point company has grown from one small hydroseeder and trailer to a broader site-services operation serving southwestern New York and northwestern Pennsylvania. It also manufactures patented Re-Tire weed-control mats from recycled waste tires, offering a way to reduce landfill waste while limiting herbicide use.
Founded in 1990, Chautauqua Woods is a woman- and minority-owned family business rooted in Western New York’s woodworking tradition. The Khan family remains closely involved in the company, whose in-house team creates made-to-order solid wood doors for distinctive homes and historically important institutions across the United States.
Since its founding in West Babylon in 1972, Check-Mate Industries has grown from a precision tool and die shop into an American manufacturer known especially for firearm magazines. Today, its 300-plus employees work across two U.S. facilities totaling 250,000 square feet, supporting government and commercial customers that need tightly controlled production for demanding applications.
Known for its patented Checklist Board design, Checklist Boards Corporation works with healthcare professionals to make critical procedures easier to follow. The Rochester company produces custom acrylic boards for hospitals and other healthcare facilities, with a red-to-green slider that gives a physical and audible signal as each step is completed. Its boards are currently used at more than 75 VA and U.S. Armed Forces facilities.
Since 1997, Checkomatic has manufactured and shipped customizable business and personal checks, including formats designed for QuickBooks and other accounting software. The company also produces related banking supplies, while its in-house production model supports custom logos, software formatting, and rush orders. Checkomatic says it has sold more than 520 million checks and envelopes and that 90.4% of clients returned over the past 25 years.
Checkpoint Therapeutics, Inc. is a Waltham, Massachusetts biopharmaceutical company developing cancer medicines, including the anti-PD-L1 antibody cosibelimab and the investigational EGFR inhibitor olafertinib. Its work centers on oncology therapies designed to engage the immune response or target specific tumor mutations, with earlier-stage programs also in development. Sun Pharma completed its acquisition of Checkpoint Therapeutics on May 30, 2025.
Checon, LLC is a U.S.-based manufacturer of electrical contacts and contact materials, vertically integrated from material formulation through final assembly. The company produces silver alloy and refractory contact materials, precision electrical contacts, contact tapes, and bus bar assemblies with integrated contacts for industrial control, power distribution, and electrification markets. Checon is part of Alloy Holdings and operates an ISO 9001 certified facility in North Attleboro, Massachusetts.
Born from Leah’s 13-year restaurant on Syracuse University’s Hill, Cheeky Monkey Foods makes its signature tomato garlic oil and other inventive seasonings in Syracuse, New York. The company’s Pixie Dust seasoning traces back to the eatery’s fresh-cut fries and corn tortillas and has been part of the business for 20 years, while its products are now available through hundreds of outlets and online.
Cheesecake Heaven is a Poughquag, New York home-based bakery making fresh-to-order cheesecakes from a family recipe first shared as holiday gifts, parties, and treats for friends. Established in 2013, the business has grown that original plain cheesecake into more than 20 flavors, including seasonal creations and custom cakes for celebrations, while retaining its hand-packed graham cracker crust and homemade character. It serves the Hudson Valley with cakes made without artificial ingredients.
Founded in 1990 by former Bloomingdale’s buyer Mona Perlhagen, Chelsea Textiles creates hand-embroidered fabrics and traditionally inspired furniture that faithfully reinterpret antique and early-20th-century designs. This family firm pairs authentic materials with master craftsmanship, with Mona’s daughter Jenny Simpson serving as chief designer since 2005 and carrying the work into contemporary interiors.
Founded in 1994, Chem-Master International is a privately held Hauppauge research, development and manufacturing company that provides contract work in organic and medicinal chemistry. Its scientist-owned team includes 14 full-time Ph.D. scientists and draws on 75 years of combined industrial and academic research experience. Operating from a 2,000-square-foot laboratory associated with Stony Brook University’s Long Island High Technology Incubator, the company develops custom compounds and scalable chemical processes for pharmaceutical, biotechnology and academic clients.
Chembio Diagnostic Systems, a Medford, New York subsidiary of Biosynex, develops and manufactures rapid point-of-care diagnostic tests for detecting and monitoring disease. Its proprietary Dual Path Platform (DPP®) technology supports simple tests that can use a small blood sample and deliver results in about 15 minutes, including the FDA-approved, CLIA-waived DPP® HIV-Syphilis test. Chembio serves clients worldwide through offices and partners and also applies its diagnostic platform to veterinary testing.
ChemCubed is a Nesconset, New York company built around a collaborative team with more than 25 years of experience in the printing industry. It develops additive-manufacturing solutions for organizations pursuing printed electronics and custom end-use components, with work spanning tailored materials and integrated printing systems. Its leadership also provides practical guidance on formulation, scale-up, and difficult materials-process problems.
Since 1975, Chemenergy Water Treatment has provided water-treatment programs, chemical engineering and technical support for commercial buildings and industrial facilities. The Albany company began as a boiler-cleaning and treatment business and is now in its third generation of Fleig family leadership, with a distinctive focus on solid encapsulated water-treatment systems alongside ongoing service agreements. Its technicians work with facility operators worldwide to protect water-based equipment and improve plant performance.
Established in 1953, Chemical Distributors, Incorporated is an independently owned Buffalo chemical distributor that also blends chemicals and supplies industrial processing equipment. Its 116,000-plus square feet of warehousing and blending space, company truck fleet, on-site laboratory and Northeast location support regional delivery as well as worldwide equipment shipments. CDI is a member of the National Association of Chemical Distributors and follows the Responsible Care Initiative.
Incorporated in 1981, Chemite, Inc. is a small New York manufacturer of more than 1,200 specialty industrial chemistries, custom-formulated largely for private-label customers. Its 32,000-square-foot plant in Chemung County supports tailored cleaning and treatment solutions, with laboratory pre-testing and chemist assistance for on-site process installation. Chemite also serves local accounts and janitorial markets while emphasizing personnel safety and environmental considerations in product development.
Established in 1989, Chemlube International LLC trades and distributes base oils worldwide from its Harrison, New York headquarters, supplying customers that range from oil companies to lubricant blenders. Its international operation combines procurement expertise with logistics support, and the company is also a manufacturer of finished lubricants. Chemlube is the sole distributor of ADNOC Group III+ base oils in Europe.