Founded by biomedical imaging expert David Wilson, PhD, BioInVision is a Cleveland company built around technology developed with Case Western Reserve University. Its CryoViz™ platform helps biotechnology and pre-clinical researchers examine whole mice or organs in three dimensions at microscopic resolution, while the company also applies its imaging expertise to clinical cardiac software.
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CPSI BiotechFounded by cryomedicine researcher John M. Baust, Ph.D., CPSI Biotech is an Owego technology-development company creating investigational cryo-medical devices and life-science research products. Its work combines cryobiology with medical-device engineering for applications in cancer treatment, cardiovascular care, and cell-therapy bioprocessing. CPSI’s pipeline includes more than 10 prototype devices, which it advances toward commercialization through partnerships, licensing, and contract research.OWEGO, NY
Clear Image TechnologyClear Image Technology develops direct-visualization medical imaging systems, including the portable C Scope® 2.2mm single-use arthroscope, from its base in Westlake, Ohio. The company says more than 10 years of work in medical imaging led to its modular hardware and software platform, designed to give physicians real-time views during diagnosis and treatment. Its systems are aimed at making needle arthroscopy more accessible across offices, procedure rooms, surgery centers, and operating rooms.WESTLAKE, OH
Akrotome ImagingIncorporated in Delaware in late 2008, Cleveland-based Akrotome Imaging develops fluorescent molecular probes that help surgeons see cancer and its margins during resection. Its patented FIRE platform uses quenched probes that activate when they encounter tumor-associated enzymes, with the flexibility to be applied in the operating room and used alongside a near-infrared imaging system. The company’s current team has been in place since 2012 and is translating the technology toward breast and non-melanoma skin cancer applications.CLEVELAND, OH
Intracellular Imaging, IncBased in Cincinnati, Intracellular Imaging makes fluorescence imaging and photometry systems for researchers measuring intracellular calcium and other cellular signals. Its InCyt systems combine microscope-based imaging with photometry options, and the company is known for equipment that researchers can learn quickly alongside responsive service and support. Intracellular Imaging also develops application guidance to help laboratories choose between spatially resolved imaging and faster, more sensitive photometry.CINCINNATI, OH