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A Cincinnati family business, Down Decor is known for developing distinctive bedding materials while manufacturing in the United States. Its factory serves retailers and private-label home-goods brands, with customization and product-development support built around each customer’s needs.
Since opening in 2017, lifelong butcher Greg Hangac has built Down the Road Butchery around the Hudson Valley values he learned in a hunting family: honest work, humane handling, and respect for both customers and animals. His Milan shop is known for careful, high-yield meat processing for hunters and local farms, helping keep food connected to the land and the families who depend on it.
Working from Brooklyn’s Navy Yard, Downing Frames is an art-framing studio known for treating each piece as a collaboration with its artist, curator, or collector. Its team creates custom frames using conservation framing practices and serves clients across New York’s gallery, museum, and auction worlds.
Founded by Mordechai Fried in 1975, Downright makes down bedding and fine linens by hand in its Brooklyn studio. Now a family business with sons Sol and Shmiel alongside its founder, the company still fills, fluffs and inspects made-to-order pillows and comforters in-house, supplying both homes and luxury hospitality partners. Downright has grown from a two-person basement operation to a roughly 50-person Brooklyn manufacturer while preserving its small-workshop approach.
Downright Printing is a New York City, women- and minority-owned shop producing custom apparel and branded merchandise in-house, with screen printing and embroidery handled under one roof. Its New Hyde Park operation also stores, packs, and ships merchandise for brands, giving customers one partner from the press to the doorstep. The company says it serves more than 500 brands, teams, and organizations, with low minimums starting at 24 pieces.
Downtown Custom Printwear provides in-house custom screen printing, embroidery, large-format printing, vinyl graphics, promotional gear, and graphic design. It customizes apparel, team gear, corporate apparel, tactical gear, promotional items, banners, lawn signs, and window graphics for businesses, organizations, teams, and individuals.
Founded by Ted Peterson as a basement-based holiday décor business, Downtown Decorations Inc. remains a family-run company with his son Garrett joining in 2003. The Syracuse-based firm has since grown from small-town municipal work into a custom design house serving public and commercial spaces across the United States and internationally, while retaining the hands-on character of its beginnings.
From its New York base, Doxon Manufacturing Co. makes and supplies commercial laundry replacement parts to distributors and wholesalers worldwide. With more than 50 years in the laundry-parts business, the company combines original and aftermarket products with a large in-stock inventory and a team that helps customers identify the right part. Doxon also marks OEM-quality “Inside Items” with a lowest-price guarantee.
Doyle & Roth Manufacturing Company designs and fabricates tubular heat-transfer equipment, including shell-and-tube heat exchangers and pressure vessels. Established in 1932, the women-owned company reports producing approximately 300–400 exchangers and pressure vessels annually for customers across varied industries. Its fabrication facility in Simpson, Pennsylvania, has operated since the 1960s.
Founded in 1982, Doyle Sails makes custom sails for boats ranging from dinghies to superyachts, pairing hands-on sailing knowledge with a global loft network. Its Auckland operation designs and builds Stratis membranes in an 11,000-square-metre facility, while local lofts provide fitting, repair and maintenance for sailors around the world. Doyle also gives retired sails a second life through sustainable luggage made from repurposed sailcloth.
Founded in 2021 by Giovanni Cozzi and his son Alessandro, Dr Zero Zero makes Italian-inspired non-alcoholic aperitivo and digestivo drinks. Crafted in Italy with botanical extracts and citrus, its AmarNo brings the bitter herbal character of an after-dinner amaro, while AperZero recreates the bright, bittersweet aperitivo tradition before a meal. The company works with Liquorificio Italia in Trieste and has grown to more than 350 retail, restaurant, and bar placements across five locations.
Founded by German doctor and orthopedics specialist Dr. Barbara Sturm, the company makes Molecular Cosmetics skincare rooted in anti-inflammatory science. Dr. Sturm brought her clinical research into aesthetics in 2002, creating the MCX PRP facial and plasma-based MC1 cream before launching the full collection in 2014. Today, the brand operates seven Spa & Boutiques worldwide and offers personalized routines, treatments, and skincare education alongside its products.
Dr. Idriss creates science-backed skincare solutions led by board-certified dermatologist Dr. Shereene Idriss, the New York City dermatologist known online as the #PillowtalkDerm. The brand grew from her myth-busting videos filmed from bed into a global community of more than 3 million, with products formulated to address concerns such as dark spots and redness. Its clinically tested, dermatologist tested, allergy tested, fragrance-free formulas reflect a deliberately straightforward approach to skincare education.
Born from their son’s eczema, Lucy and Joe Aini founded Dr. Jacobs Naturals in Brooklyn in 2011 to make gentle, natural personal-care products, beginning with vegetable-based Castile soaps for sensitive skin. The family-run brand now also makes products such as baby eczema soap and Belly Jelly, a baby ultrasound and stretch-mark gel developed with sister-in-law Freda Smeke. Its products are made in the USA and emphasize vegan, cruelty-free formulas free of palm oil and common additives such as parabens, phthalates, artificial dyes and fragrances.
Dr. Konstantin Frank Winery makes Finger Lakes wines from vineyards overlooking Keuka and Seneca lakes, where its founder planted some of the Eastern United States’ first vinifera vines in 1957. The four-generation Frank family winery is especially known for Riesling, traditional-method sparkling wine, and old vines first planted in 1958, with many still producing today. Its dry-farmed vineyards follow Cornell’s VineBalance sustainability recommendations, and visitors can explore the legacy through tastings and the garden named for first-generation owner Eugenia Frank.
Dr. Lara Devgan Skincare is the small Upper East Side team behind Dr. Lara Devgan’s scientific beauty line, closely connected to her New York City plastic surgery practice. Founded on her medical expertise, the company creates luxury skincare with clinically oriented ingredients for people seeking targeted, physician-developed care at home.
Founded around the work of dermatologist-scientist Macrene Alexiades, MD, PhD, DR. MACRENE actives makes dermatologist-developed skincare designed to bring clinical research into everyday formulas. The New York company’s products are built around its patented MA37™ multi-active technology and plant-derived ingredients, while its Manhattan and Wainscott spas extend that approach into personalized treatments. Alexiades holds BA, MD, and PhD degrees from Harvard and is dual board-certified in dermatology in the United States and European Union.
Dr. Michelle Copeland Skin Care grew from a New York plastic surgeon’s effort to formulate better post-surgical skincare for her patients, and now makes physician-developed regimens for everyday skin health. Dr. Copeland, a Harvard-trained biochemist and the first woman plastic surgeon to create a full skincare line, personally develops and tests the formulas, including the long-standing AHA Face Cream and treatments for discoloration and scarring. The line is allergy tested, fragrance free, and made without animal testing.
A fourth-generation company rooted in Germany since 1886, Dr. Paul Lohmann GmbH & Co. KGaA has grown from its origins producing high-purity iron for medical use into a specialist manufacturer serving customers worldwide. Based in Emmerthal, with production in Lüneburg since 1972, it makes mineral and metal salts for pharmaceutical, food and industrial applications, all produced exclusively in Germany. Its facilities have held GMP certification since 1994 and are also certified to DIN EN ISO 9001.
Dr. WellMe Nutritions Inc. develops and sells Made-in-USA vitamins, supplements and nootropics for everyday wellness, including targeted formulas such as its PregWell prenatal and Probiolise probiotic capsules. Based in Congers, New York, the company says its products are manufactured at GMP-approved sites, with every batch tested by its quality-control team for purity and quality. Its range is organized around health needs from bone and brain support to pediatric and men’s wellness, and the company also highlights experience with international market documentation and export.